In the Department of Plastic Surgery, First Affiliated Hospital of Zhengzhou University, in Zhengzhou, China, Zong Chen, BS, and Zhi-You Chen, BS, are postgraduate students; Wen-Hui Liu, MD, is Assistant Professor; and Guang-Shuai Li, MD, PhD, is Professor. Acknowledgment: This work was supported by Science and Technology Department of Henan Province (CN) (grant 201702040 and 182102310085). The authors have disclosed no other financial relationships related to this article. Submitted September 24, 2019; accepted in revised form November 14, 2019.
Adv Skin Wound Care. 2020 Nov;33(11):608-612. doi: 10.1097/01.ASW.0000695784.82605.1e.
To evaluate the effectiveness of electric stimulation (ES) for diabetic foot ulcer (DFU) treatment.
The authors searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases for randomized clinical trials published through March 2019 that compared the efficacy of ES and standard wound care (SWC) versus SWC alone for DFU treatment. The outcomes were pooled using a random-effects model.
Of the 145 randomized clinical trials initially identified, seven studies (with a total of 274 patients) met the inclusion criteria. The percentage decrease in ulcer area at 4 weeks was significantly greater in patients treated with ES and SWC than SWC alone (standardized mean difference, 1.09; 95% confidence interval, 0.62-1.57; P < .001). The ulcer healing rate at 12 weeks was also significantly faster in the ES group (risk difference, 0.19; 95% confidence interval, 0.06-0.32; P = .005). Subgroup analysis showed comparable efficacies with different waveforms (monophasic vs biphasic).
Electrical stimulation appears to be an effective adjunctive therapy for accelerating DFU healing.
评估电刺激（ES）治疗糖尿病足溃疡（DFU）的效果。
作者检索了 MEDLINE、EMBASE、Cochrane 对照试验中心注册库和 ClinicalTrials.gov 数据库，以评估 2019 年 3 月之前发表的比较 ES 与标准伤口护理（SWC）联合治疗与 SWC 单独治疗 DFU 效果的随机临床试验。使用随机效应模型汇总结果。
最初确定的 145 项随机临床试验中，有 7 项研究（共 274 名患者）符合纳入标准。与 SWC 单独治疗相比，ES 联合 SWC 治疗 4 周时溃疡面积的百分比下降更显著（标准化均数差，1.09；95%置信区间，0.62-1.57；P<0.001）。ES 组的溃疡愈合率在 12 周时也明显更快（风险差，0.19；95%置信区间，0.06-0.32；P=0.005）。亚组分析显示，不同波形（单相波与双相波）的疗效相当。
电刺激似乎是一种有效的辅助治疗方法，可加速 DFU 愈合。
