Hecquet B
Pathol Biol (Paris). 1987 Jun;35(6):937-41.
The concept of rhythm can be introduced in the mathematic models describing pharmacological phenomena. The modelling can take into account periodic fluctuations in the pharmacokinetic parameters (chronopharmacokinetics), or periodic fluctuations in the susceptibility of an organism to a drug (chronesthesy). It allows to choose the theoretical cases when chronotherapy could be particularly usefull, and also to propose protocols of administration taking into account the time (injection clock-time for example), in the same way that drug amount and route of administration. Modelisation also shows up the complex relationship between a temporally structured organism and an exogenous substance which has not been designed to be integrated into a set of biological rhythms.
节律的概念可以引入到描述药理学现象的数学模型中。建模可以考虑药代动力学参数的周期性波动（时辰药代动力学），或生物体对药物敏感性的周期性波动（时辰感受性）。这使得我们能够选择时辰治疗可能特别有用的理论情况，并像考虑药物剂量和给药途径一样，提出考虑时间因素（例如注射时间）的给药方案。建模还揭示了一个具有时间结构的生物体与一种并非设计用于融入生物节律系统的外源性物质之间的复杂关系。
