Bureau J P, Coupe M, Labrecque G, Vago P
Pathol Biol (Paris). 1987 Jun;35(6):942-50.
The inflammatory reaction is characterized by a multifrequency time structure with prominent circadian, ultradian and infradian rhythms in cell proliferation and cell function. The circulating blood cells show highly reproducible circadian rhythms in human and in animals. Daily fluctuations of concentrations of haematologic chemical and endocrinological parameters are described. Circannual variations of several hematologic parameters are presented. Chronobiological studies of plasma exudation in carrageenan paw oedema show a circadian and a circannual rhythm. Daily and annual changes in migration of polymorphonuclear leucocyte produced by BCG are studied in mice. Differences in response are observed in adrenalectomized and castrated animals. The susceptibility of cells and tissues at different stages of their circadian or circannual rhythms lead to the development of a chronotherapy of inflammation.
炎症反应的特征是具有多频时间结构，在细胞增殖和细胞功能方面存在显著的昼夜节律、超日节律和亚日节律。循环血细胞在人类和动物中显示出高度可重复的昼夜节律。描述了血液学化学和内分泌参数浓度的每日波动情况。呈现了几种血液学参数的年周期变化。对角叉菜胶爪水肿中血浆渗出的时间生物学研究显示出昼夜节律和年周期节律。在小鼠中研究了卡介苗引起的多形核白细胞迁移的每日和年度变化。观察到肾上腺切除和阉割动物的反应差异。细胞和组织在其昼夜节律或年周期节律不同阶段的易感性导致了炎症时间疗法的发展。
