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韧性不能调节儿童时期逆境经历与晚年抑郁症之间的关联。爱尔兰老龄化纵向研究(TILDA)的发现。

Resilience does not mediate the association between adverse childhood experiences and later life depression. Findings from the Irish Longitudinal Study on Ageing (TILDA).

机构信息

The Irish Longitudinal Study on Ageing (TILDA), Lincoln Gate, Trinity College Dublin, Ireland.

The Irish Longitudinal Study on Ageing (TILDA), Lincoln Gate, Trinity College Dublin, Ireland.

出版信息

J Affect Disord. 2020 Dec 1;277:901-907. doi: 10.1016/j.jad.2020.08.089. Epub 2020 Sep 7.

Abstract

BACKGROUND

Resilience has been found to moderate the association between childhood trauma and later depression. We examined whether resilience mediates the association between Adverse Childhood Experiences (ACEs) and later life depression among older adults.

METHODS

Data were from The Irish Longitudinal Study on Ageing (TILDA), a prospective study of 8,500 community-dwelling adults aged ≥ 50 years. Negative binomial regressions were used to examine the relationships between ACEs, resilience, and depression and path analysis was conducted to test the potential mediating effect of resilience on the association between ACEs and depressive symptoms.

RESULTS

Mean CES-D8 depression score was 3.3 from a maximum of 24. The average resilience score from a maximum of 15 was 8.9. 26.0% of participants had experienced at least one ACE before the age of 18. A history of ACEs was associated with increased depressive symptomology. The strongest association was between physical abuse and depressive symptoms followed by sexual abuse, parental drug or alcohol use, and childhood poverty. Our path analyses showed that there was no evidence that resilience mediated the association between ACEs and depressive symptoms among this cohort.

LIMITATIONS

Information on ACEs was collected retrospectively. The resilience measure depended on experience of stressful life events in the last five years and therefore some participants were excluded.

CONCLUSIONS

ACEs were associated with an increased likelihood of late-life depressive symptoms. Higher resilience was associated with decreased likelihood of late-life depressive symptoms. A history of ACEs is associated with lower resilience. The association between ACEs and late-life depressive symptoms is not mediated by resilience.

摘要

背景

韧性已被发现可以调节儿童期创伤与后期抑郁之间的关系。我们研究了韧性是否可以调节老年人中逆境经历(ACEs)与晚年抑郁之间的关系。

方法

数据来自爱尔兰老龄化纵向研究(TILDA),这是一项针对 8500 名 50 岁以上社区居民的前瞻性研究。我们使用负二项回归来检验 ACEs、韧性和抑郁之间的关系,并进行路径分析以检验韧性对 ACEs 与抑郁症状之间关联的潜在中介作用。

结果

CES-D8 抑郁评分的平均值为 3.3(满分 24 分)。15 分制的平均韧性评分为 8.9。26.0%的参与者在 18 岁之前经历过至少一次 ACE。ACEs 史与抑郁症状增加有关。最强的关联是身体虐待和性虐待,其次是父母吸毒或酗酒以及童年贫困。我们的路径分析表明,在该队列中,韧性不能介导 ACEs 与抑郁症状之间的关联。

局限性

ACEs 的信息是回顾性收集的。韧性的衡量标准取决于过去五年中经历的压力生活事件,因此一些参与者被排除在外。

结论

ACEs 与晚年抑郁症状的发生几率增加有关。较高的韧性与晚年抑郁症状的发生几率降低有关。ACEs 史与韧性降低有关。ACEs 与晚年抑郁症状之间的关联不受韧性的影响。

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