Division of Molecular Biology, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia.
Division of Molecular Biology, Faculty of Science, University of Zagreb, HR-10000 Zagreb, Croatia.
Cells. 2020 Oct 13;9(10):2279. doi: 10.3390/cells9102279.
Non-bilaterian animals consist of four phyla; Porifera, Cnidaria, Ctenophora, and Placozoa. These early-diverging animals are crucial for understanding the evolution of the entire animal lineage. The Rho family of proteins make up a major branch of the Ras superfamily of small GTPases, which function as key molecular switches that play important roles in converting and amplifying external signals into cellular responses. This review represents a compilation of the current knowledge on Rho-family GTPases in non-bilaterian animals, the available experimental data about their biochemical characteristics and functions, as well as original bioinformatics analysis, in order to gain a general insight into the evolutionary history of Rho-family GTPases in simple animals.
多孔动物门、刺胞动物门、栉水母动物门和扁盘动物门。这些早期分化的动物对于理解整个动物谱系的进化至关重要。Rho 家族蛋白构成 Ras 超家族小 GTP 酶的一个主要分支，作为关键的分子开关，在将外部信号转化为细胞反应并进行放大方面发挥着重要作用。本综述代表了非双侧对称动物 Rho 家族 GTP 酶的当前知识的汇编，包括关于它们的生化特性和功能的现有实验数据，以及原始的生物信息学分析，以便更全面地了解简单动物中 Rho 家族 GTP 酶的进化历史。
