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营养支持系统(饮食与补充剂)对改善脑瘫患儿粗大运动功能的影响:一项探索性随机对照临床试验。

Effect of a Nutritional Support System (Diet and Supplements) for Improving Gross Motor Function in Cerebral Palsy: An Exploratory Randomized Controlled Clinical Trial.

作者信息

Leal-Martínez Fernando, Franco Denise, Peña-Ruiz Andrea, Castro-Silva Fabiola, Escudero-Espinosa Andrea A, Rolón-Lacarrier Oscar G, López-Alarcón Mardia, De León Ximena, Linares-Eslava Mariana, Ibarra Antonio

机构信息

Centro de Investigación en Ciencias de la Salud (CICSA), FCS, Universidad Anáhuac México Norte, Huixquilucan 52786, Mexico.

Departamento de Terapia Física, Centro de Rehabilitación e Inclusión Infantil Teletón (CRIT), Tlalnepantla de Baz 54010, Mexico.

出版信息

Foods. 2020 Oct 13;9(10):1449. doi: 10.3390/foods9101449.

Abstract

BACKGROUND

Most patients with cerebral palsy (CP) do not respond to physical therapy due to deterioration in their nutritional status, secondary to gastrointestinal disorders and the catabolic state of the disease itself. However, basic treatments only contemplate the energy requirements and do not consider supplementation with glutamine, zinc, selenium, colecalciferol, spirulina, omega 3 or even vegetal proteins.

OBJECTIVE

In this study, we determined the effect of using a nutritional support system (NSS): diet and supplements, on the gross motor function in children with CP with spastic diparesic and Gross Motor Function Classification System III (GMFCS III).

METHODS

An exploratory study was performed. Thirty patients (from 4 to 12 years old) were randomly assigned to: (1) dietary surveillance (FG), (2) deworming and WHO diet (CG), or (3) deworming and the NSS (IG). Gross motor function was evaluated using the gross motor function measure (GMFM) scale.

RESULTS

The IG-treated group presented a significant improvement in standing and walking parameters analyzed in the GMFM compared with FG and CG groups. Fifty percent of the IG-treated patients managed to walk, while in the other groups, no patients were able to walk.

CONCLUSIONS

The NSS used in the present work improves gross motor function and promotes walking in patients with CP.

摘要

背景

大多数脑瘫(CP)患者由于胃肠道疾病及疾病本身的分解代谢状态导致营养状况恶化,对物理治疗无反应。然而,基础治疗仅考虑能量需求,未考虑补充谷氨酰胺、锌、硒、骨化三醇、螺旋藻、ω-3脂肪酸甚至植物蛋白。

目的

在本研究中,我们确定了使用营养支持系统(NSS):饮食和补充剂,对痉挛性双侧瘫且粗大运动功能分类系统为III级(GMFCS III)的脑瘫患儿粗大运动功能的影响。

方法

进行了一项探索性研究。30例患者(4至12岁)被随机分为:(1)饮食监测组(FG),(2)驱虫和世界卫生组织饮食组(CG),或(3)驱虫和营养支持系统组(IG)。使用粗大运动功能测量(GMFM)量表评估粗大运动功能。

结果

与FG组和CG组相比,IG治疗组在GMFM中分析的站立和行走参数有显著改善。50%接受IG治疗的患者能够行走,而其他组中没有患者能够行走。

结论

本研究中使用的营养支持系统改善了脑瘫患者的粗大运动功能并促进了行走。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6375/7601161/e7041dd05437/foods-09-01449-g001.jpg

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