Lima de Albuquerque Lidio, Pantovic Milan, Clingo Mitchel, Fischer Katherine, Jalene Sharon, Landers Merrill, Mari Zoltan, Poston Brach
Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
School of Medicine, University of Nevada Las Vegas, Las Vegas, NV 89102, USA.
Brain Sci. 2020 Oct 14;10(10):735. doi: 10.3390/brainsci10100735.
Transcranial direct current stimulation of the cerebellum (c-tDCS) improves motor performance in young and old adults. Based on the cerebellar involvement in Parkinson's disease (PD), c-tDCS could have potential to improve motor function in PD. The purpose was to determine the effects of c-tDCS on motor performance in PD while participants were on medications. The study was a randomized, double-blind, SHAM-controlled, between-subjects design. Twenty-two participants with PD were allocated to either a c-tDCS group or a SHAM group. All participants completed one experimental session and performed two motor tasks with their most affected hand in a Baseline condition (no stimulation) and an Experimental condition. The motor tasks were a visuomotor isometric precision grip task (PGT) and a rapid arm movement task (AMT). The primary dependent variables were force error and endpoint error in the PGT and AMT, respectively. There were no significant differences in force error or endpoint error in the Experimental condition between the c-tDCS and SHAM groups. These results indicate that an acute application of c-tDCS does not enhance motor performance in hand and arm tasks in PD. Longer-term c-tDCS application over multiple days may be needed to enhance motor function in PD.
经颅直流电刺激小脑（c-tDCS）可改善年轻人和老年人的运动表现。鉴于小脑与帕金森病（PD）有关，c-tDCS可能具有改善PD患者运动功能的潜力。本研究的目的是确定在患者服用药物期间，c-tDCS对PD患者运动表现的影响。该研究采用随机、双盲、假刺激对照的组间设计。22名PD患者被分配到c-tDCS组或假刺激组。所有参与者均完成一个实验环节，并在基线状态（无刺激）和实验状态下，用受影响最严重的手执行两项运动任务。运动任务为视觉运动等距精确抓握任务（PGT）和快速手臂运动任务（AMT）。主要因变量分别为PGT和AMT中的用力误差和终点误差。在实验状态下，c-tDCS组和假刺激组之间的用力误差或终点误差无显著差异。这些结果表明，急性应用c-tDCS并不能增强PD患者手部和手臂任务的运动表现。可能需要在多天内长期应用c-tDCS来增强PD患者的运动功能。
