Safi F, Roscher R, Bittner R, Schenkluhn B, Dopfer H P, Beger H G
Pancreas. 1987;2(4):398-403. doi: 10.1097/00006676-198707000-00006.
The serum carbohydrate antigenic determinant (CA 19-9) was assayed in patients with various diseases (87 patients with pancreatic carcinoma, 747 patients with benign diseases, and 547 patients with extrapancreatic malignant growths) and it proved to be particularly sensitive for adenocarcinoma of the pancreas (80 of 87, 92%) as compared to only 14% in the group of patients with benign diseases. Twenty-seven percent of the patients with chronic pancreatitis and 28% of the patients with acute pancreatitis showed elevated CA 19-9 concentrations of more than the upper normal value of 37 U/ml. In 38% and 32% of our cases with carcinoma of the stomach and colorectal carcinoma, respectively, CA 19-9 was estimated as being above the normal range. The preoperatively raised CA 19-9 concentration in patients with pancreatic carcinoma decreases after curative resection of the carcinoma to values within the normal range. However, in no CA 19-9 estimation following a palliative surgical intervention or in cases of inoperable carcinomas a serum concentration of less than 37 U/ml was recorded. In immunohistochemical specimens we found a difference between CA 19-9 antigen concentrations on the cell surface and secretion in pancreatic carcinoma and chronic pancreatitis.
对患有各种疾病的患者（87例胰腺癌患者、747例良性疾病患者和547例胰腺外恶性肿瘤患者）检测了血清碳水化合物抗原决定簇（CA 19-9），结果证明它对胰腺癌特别敏感（87例中有80例，92%），相比之下，良性疾病患者组中只有14%。27%的慢性胰腺炎患者和28%的急性胰腺炎患者的CA 19-9浓度升高超过正常上限值37 U/ml。在我们的病例中，分别有38%的胃癌患者和32%的结直肠癌患者的CA 19-9估计高于正常范围。胰腺癌患者术前升高的CA 19-9浓度在癌灶根治性切除后降至正常范围内的值。然而，在姑息性手术干预后的CA 19-9检测中，或在无法手术切除的癌灶病例中，未记录到血清浓度低于37 U/ml的情况。在免疫组织化学标本中，我们发现胰腺癌和慢性胰腺炎细胞表面和分泌物中的CA 19-9抗原浓度存在差异。
