Division of Pulmonary Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Lung. 2020 Dec;198(6):957-964. doi: 10.1007/s00408-020-00396-5. Epub 2020 Oct 16.
People with cystic fibrosis (CF) are predisposed to chronic conditions, such as CF-related diabetes (CFRD). Recent attention has been focused on the addition of screening for anxiety and depression in the CF population. Independently, CFRD and mental health conditions are associated with worse clinical outcomes; however, research assessing the impact of both conditions together is limited. We aimed to characterize the association between CFRD and selected diagnoses of anxiety or depressive disorders on clinical outcomes in adults with CF.
A single-center, retrospective, cross-sectional study in adult patients with CF was performed. Group comparisons included selected diagnoses of depression, anxiety, and CFRD using two-sample t-tests or rank-sum tests for continuous variables, and Chi-square or Fisher's exact tests for categorical variables.
A total of 209 adults were enrolled (mean age of 31.4 ± 11.4 years). Those with a selected diagnoses of depression had a significantly higher proportion of CFRD than those without depression (48% vs. 28%, respectively, p = 0.005), and CFRD was associated with increased odds of depression [OR (CI) = 2.33 (1.28, 4.26), p = 0.006]. We did not see a higher proportion of adults with CFRD and selected diagnoses of anxiety than those without anxiety (41% vs. 31% respectively, p = 0.12), nor an increased odds of anxiety in those with CFRD [OR (CI) = 1.58 (0.88, 2.84), p = 0.12].
We show a significant association between CFRD and selected diagnoses of depression in a cohort of adult patients.
囊性纤维化 (CF) 患者易患慢性疾病，如 CF 相关糖尿病 (CFRD)。最近，人们关注的焦点是在 CF 人群中增加焦虑和抑郁的筛查。独立地，CFRD 和心理健康状况与更差的临床结局相关；然而，评估这两种情况同时存在的影响的研究是有限的。我们旨在描述 CFRD 与 CF 成人中某些焦虑或抑郁障碍诊断之间的关联对临床结局的影响。
对 CF 成人患者进行了一项单中心、回顾性、横断面研究。组间比较包括使用两样本 t 检验或秩和检验比较连续变量，使用卡方或 Fisher 精确检验比较分类变量的抑郁、焦虑和 CFRD 的特定诊断。
共纳入 209 名成年人（平均年龄为 31.4±11.4 岁）。有抑郁特定诊断的患者中 CFRD 的比例明显高于无抑郁的患者（分别为 48%和 28%，p=0.005），并且 CFRD 与抑郁的可能性增加相关 [比值比 (OR)（置信区间）=2.33（1.28，4.26），p=0.006]。我们没有看到 CFRD 和某些焦虑诊断的成年人比例高于无焦虑的成年人（分别为 41%和 31%，p=0.12），也没有看到 CFRD 患者焦虑的可能性增加 [比值比 (OR)（置信区间）=1.58（0.88，2.84），p=0.12]。
我们在一组成年 CF 患者中显示了 CFRD 与某些抑郁诊断之间的显著关联。
