University College of Veterinary and Animal Sciences, Narowal, 51600, Pakistan.
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Curr Issues Mol Biol. 2021;41:597-616. doi: 10.21775/cimb.041.597. Epub 2020 Oct 17.
Tuberculosis is a devastating disease causing high mortality all over the world, especially in the developing countries. () is the causative agent of tuberculosis which replicates in the intracellular environment of host macrophages. Although the host immune system is capable of completely eliminating the pathogen, co-evolution of with humans has resulted in its ability to hijack the host innate and adaptive immune systems in numerous ways. Limited recent progress has been made in the understanding of immune escape mechanisms, hence exploration of survival strategies of has been critically reviewed with an insight into understanding its pathogenesis. We summarized the recent studies regarding the modulation of innate immune response, adaptive immune response, epigenetics and the role of miRNA. All of these advancements suggest that is well-familiarize with the host immune system and possess the ability to hijack it for intracellular survival.
结核病是一种毁灭性疾病，在世界各地，尤其是在发展中国家，导致高死亡率。结核分枝杆菌是结核病的病原体，它在宿主巨噬细胞的细胞内环境中复制。尽管宿主免疫系统能够完全清除病原体，但结核分枝杆菌与人类的共同进化导致其能够以多种方式劫持宿主先天和适应性免疫系统。目前对免疫逃避机制的理解进展有限，因此对结核分枝杆菌生存策略的探索进行了批判性的回顾，以深入了解其发病机制。我们总结了最近关于固有免疫反应、适应性免疫反应、表观遗传学和 miRNA 作用的研究。所有这些进展表明，结核分枝杆菌非常熟悉宿主免疫系统，并具有劫持它进行细胞内生存的能力。
