Department of ENT-Head and Neck Surgery, Institute of Medicine, T.U. Teaching Hospital, Kathmandu, Nepal, *Sikhar Biotech Company, Lalitpur, Nepal.
Sikhar Biotech Company, Lalitpur, Nepal.
JNMA J Nepal Med Assoc. 2020 Sep 27;58(229):681-685. doi: 10.31729/jnma.5132.
P16 overexpression is considered as a good prognostic marker for oropharyngeal squamous cell carcinoma. However, there are very few literatures on the prevalence and outcomes of p16 overexpression in non-oropharyngeal squamous cell carcinoma and benign head and neck tumors. The aim of our study was to estimate the hospital based prevalence of p16 positive laryngeal and pharyngeal tumors and to compare it with the prevalence of p16 expression in the non tumor tissue (tonsils).
This was a descriptive cross-sectional study. Cases of all genders >15 years presenting with malignant or benign tumors of larynx and all the subsites of pharynx were included in the study for evaluation of p16 expression by immunohistochemistry. Tonsillar tissue of cases undergoing tonsillectomy for recurrent acute tonsillitis were taken as non-tumorous tissue to evaluate for p16 expression.
A total of 48 cases were included in our study with 24 cases having different tumors of head and neck region and 24 cases having recurrent acute tonsillitis who were kept under non-tumor group. Eight cases (33.3%) in the tumor group showed positive stain for p16 in IHC. In non tumor group, 7 cases (29.1%) showed positive IHC staining for p16.
P16 expression can be present in both benign and malignant tumors of various subsites of head and neck region and also in tonsillar tissue affected by inflammation.
P16 过表达被认为是口咽鳞状细胞癌的一个良好预后标志物。然而，关于非口咽鳞状细胞癌和良性头颈部肿瘤中 p16 过表达的流行率和结果的文献很少。我们的研究目的是评估基于医院的喉和咽部肿瘤中 p16 阳性肿瘤的流行率，并将其与非肿瘤组织（扁桃体）中 p16 表达的流行率进行比较。
这是一项描述性的横断面研究。纳入了所有年龄>15 岁的患有喉和咽的恶性或良性肿瘤的患者，通过免疫组织化学评估 p16 的表达。将因复发性急性扁桃体炎而接受扁桃体切除术的扁桃体组织作为非肿瘤组织，以评估 p16 的表达。
我们的研究共纳入了 48 例患者，其中 24 例患有头颈部不同的肿瘤，24 例患有复发性急性扁桃体炎，这些患者被归入非肿瘤组。肿瘤组中 8 例（33.3%）在 IHC 中显示出 p16 阳性染色。在非肿瘤组中，7 例（29.1%）p16 的 IHC 染色呈阳性。
p16 的表达可存在于头颈部各部位的良性和恶性肿瘤中，也可存在于受炎症影响的扁桃体组织中。
