Department of Plastic and Aesthetic Surgery, Nan Fang Hospital of Southern Medical University, 1838 North Guangzhou AV, Guangzhou, 510515, Guangdong, People's Republic of China.
Affiliated Hospital of Xiangnan University, Chenzhou, 423099, Hunan Province, People's Republic of China.
Lasers Med Sci. 2021 Jul;36(5):1085-1093. doi: 10.1007/s10103-020-03157-1. Epub 2020 Oct 17.
This study was conducted in order to compare the safety and efficacy of LLLT, 5% minoxidil, and combination therapy in the treatment of FPHL. A randomized controlled trial was developed to study the effect of LLLT on FPHL using a device called iHelmet®, which is equipped with 200 5mW laser diode source (650 nm) arrays. Ninety Ludwig's types II-III FPHL patients were randomly divided into 3 groups: LLLT group (A), 5% minoxidil group (B), and combination group(C). Hair density, hair diameter, and scalp oil-secretion were detected to evaluate the treatment effect. Significant improvement of hair density and hair diameter was observed in all stages of FPHL after treatment. Oil-secretion of the three groups was decreased after treatment. The effectiveness of reducing oil-secretion in LLLT group and combination group was higher than minoxidil group (P < 0.05). For improving hair diameter and hair density, combination group was better than LLLT and minoxidil groups. No side effects were reported. Our study illustrated that LLLT is a safe and effective treatment for FPHL. Besides, LLLT can significantly improve its efficacy when used in combination with 5% minoxidil.
本研究旨在比较低能量激光疗法（LLLT）、5%米诺地尔和联合疗法治疗女性型脱发（FPHL）的安全性和疗效。采用一种名为 iHelmet®的设备进行随机对照试验，研究 LLLT 对 FPHL 的影响。该设备配备了 200 个 5mW 激光二极管源（650nm）阵列。90 例 Ludwig Ⅱ-Ⅲ型 FPHL 患者随机分为 3 组：LLLT 组（A）、5%米诺地尔组（B）和联合组（C）。检测头发密度、头发直径和头皮油脂分泌，以评估治疗效果。所有阶段的 FPHL 患者在治疗后头发密度和直径均有显著改善。三组的油脂分泌均减少。LLLT 组和联合组减少油脂分泌的效果优于米诺地尔组（P<0.05）。在改善头发直径和密度方面，联合组优于 LLLT 组和米诺地尔组。未报告不良反应。我们的研究表明，LLLT 是治疗 FPHL 的一种安全有效的方法。此外，LLLT 与 5%米诺地尔联合使用可显著提高其疗效。
