Kaiser Michael A, Almeida Stephanie M, Rodriguez Mario, Issa Najy, Issa Naiem Tony, Jimenez Joaquin J
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
St. George's University School of Medicine, St. George's, Grenada.
Skin Appendage Disord. 2023 Mar;9(2):104-110. doi: 10.1159/000527782. Epub 2022 Dec 23.
We analyzed randomized clinical trials (RCTs) evaluating the efficacy of combined therapy with low-level light therapy (LLLT) and topical minoxidil for treatment of androgenetic alopecia (AGA).
A literature search within PubMed identified RCTs evaluating hair regrowth following LLLT and minoxidil. Selection criteria were 600-1,100 nm wavelengths, treatment time ≥16 weeks, and objective evaluation for hair regrowth.
Five RCTs compared LLLT with minoxidil (2% or 5%) to 5% minoxidil treatment or LLLT treatment. One study showed combination therapy of LLLT, and 5% minoxidil improved hair density more than monotherapy. Another found combination LLLT with 2% minoxidil induced hair regrowth equivalent to 5% minoxidil. Similarly, another study described LLLT with 5% minoxidil versus minoxidil monotherapy to increase the number of hairs with no statistical difference between groups. One trial found that combination group increased hair regrowth in the first 2 months. The last study found a statistically significant increase in hair density with combined therapy compared to monotherapy.
The studies describe either superiority or equivalence of combination therapy to minoxidil monotherapy for AGA. Early outcomes appear to support the superiority of combination therapy, but this advantage wanes at the end of the study periods.
我们分析了评估低能量激光疗法（LLLT）与外用米诺地尔联合治疗雄激素性脱发（AGA）疗效的随机临床试验（RCT）。
在PubMed上进行文献检索，以确定评估LLLT和米诺地尔治疗后毛发生长情况的RCT。选择标准为波长600 - 1100nm、治疗时间≥16周以及对毛发生长进行客观评估。
五项RCT将LLLT与2%或5%米诺地尔联合治疗与5%米诺地尔单药治疗或LLLT单药治疗进行了比较。一项研究表明，LLLT与5%米诺地尔联合治疗比单药治疗能更有效地改善头发密度。另一项研究发现，LLLT与2%米诺地尔联合治疗诱导毛发生长的效果等同于5%米诺地尔单药治疗。同样，另一项研究描述了5%米诺地尔联合LLLT与米诺地尔单药治疗相比，能增加毛发数量，但两组间无统计学差异。一项试验发现联合治疗组在最初2个月内毛发生长增加。最后一项研究发现，与单药治疗相比，联合治疗组的头发密度有统计学显著增加。
这些研究表明，对于AGA，联合治疗相对于米诺地尔单药治疗具有优势或等效性。早期结果似乎支持联合治疗的优越性，但在研究期末这种优势减弱。
