School of Medicine, Faculty of Health Sciences, Queen's University, 15 Arch St Kingston, ON, K7L 3N6 Canada; Departments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1 Canada.
Department of Biomedical and Molecular Sciences, Faculty of Arts & Science, Queen's University, 94 University Ave, Kingston, ON, K7L 3N9 Canada; Departments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1 Canada.
Physiol Behav. 2021 Feb 1;229:113198. doi: 10.1016/j.physbeh.2020.113198. Epub 2020 Oct 14.
Human neurovascular coupling research conventionally aims to selectively activate the posterior circulation using a visual task. Different research groups use divergent visual tasks ranging in complexity and eye movement patterns with potential confounding effects. To understand the role of task complexity and eye movement patterns in neurovascular coupling, we performed a series of experiments with visual tasks ranging in complexity, eye speed, and eye movement amplitude. Greater task complexity significantly reduced selectivity for the posterior circulation. Greater task amplitude (i.e. larger eye movements) increased selectivity. These findings are important when interpreting and designing neurovascular coupling investigations.
传统上，人类神经血管耦合研究旨在使用视觉任务选择性地激活后循环。不同的研究小组使用不同的视觉任务，其复杂性和眼球运动模式不同，可能会产生潜在的混杂效应。为了了解任务复杂性和眼球运动模式在神经血管耦合中的作用，我们进行了一系列实验，使用了不同复杂性、眼速和眼球运动幅度的视觉任务。任务复杂性的增加显著降低了对后循环的选择性。更大的任务幅度（即更大的眼球运动）增加了选择性。这些发现对于解释和设计神经血管耦合研究非常重要。
