Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2020 Dec;132:110853. doi: 10.1016/j.biopha.2020.110853. Epub 2020 Oct 14.
The ERK/MAPK cascade is one the four distinctive MAPK cascades which transmit extracellular signals to intracellular targets. This cascade has an important role in the regulation of several fundamental processes such as proliferation, differentiation and cell response to diverse extrinsic stresses. Moreover, several studies have shown participation of this cascade in the pathogenesis of cancer. Recent investigations have unraveled interaction between microRNAs (miRNAs) and ERK/MAPK cascade. These transcripts reside in both upstream and downstream of this cascade, regulating or being regulated by ERK/MAPK proteins. In the current review, we summarize the role of miRNAs in the regulation of ERK/MAPK and their contribution in the pathogenesis of human disorders with particular focus on cancers.
ERK/MAPK 级联是将细胞外信号传递到细胞内靶标的四个独特 MAPK 级联之一。该级联在调节几种基本过程中具有重要作用，如增殖、分化和细胞对各种外在应激的反应。此外，几项研究表明该级联参与了癌症的发病机制。最近的研究揭示了 microRNAs（miRNAs）与 ERK/MAPK 级联之间的相互作用。这些转录本位于该级联的上游和下游，通过 ERK/MAPK 蛋白进行调节或被其调节。在本综述中，我们总结了 miRNAs 在 ERK/MAPK 调节中的作用及其在人类疾病发病机制中的贡献，特别关注癌症。
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