Tataranu Ligia Gabriela
Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Neurosurgery, Bagdasar-Arseni Emergency Clinical Hospital, 041915 Bucharest, Romania.
Biomedicines. 2025 Apr 16;13(4):968. doi: 10.3390/biomedicines13040968.
Approximately 90% of the lesions of hypophyseal origins are represented by pituitary neuroendocrine tumors, which further account for up to 22.5% of the intracranial tumors in the adult population. Although the intricacy of this pathology is yet to be fully understood on a biomolecular level, it is well known that these lesions develop within a microenvironment that supports their evolution and existence. The role of the tumoral microenvironment in pituitary lesions is pivotal, mainly due to this gland's distinct anatomical, histological, and physiological structure and function. Each component of the tumoral microenvironment is specifically involved in tumorigenesis, angiogenesis, tumoral growth, progression, and dissemination. By recognizing and understanding how these elements are involved in such processes, targeted treatments can emerge, and better future management of pituitary lesions can be provided. This article aims to summarize the role of each component of the tumoral microenvironment in pituitary lesions while assessing their association with biomolecular mechanisms.
约90%的垂体起源病变为垂体神经内分泌肿瘤，在成年人群中，此类肿瘤占颅内肿瘤的比例高达22.5%。尽管这种病理学的复杂性在生物分子水平上尚未完全明了，但众所周知，这些病变是在支持其演变和存在的微环境中发展而来的。肿瘤微环境在垂体病变中的作用至关重要，这主要归因于该腺体独特的解剖、组织学和生理结构与功能。肿瘤微环境的每个组成部分都具体参与肿瘤发生、血管生成、肿瘤生长、进展和扩散过程。通过认识和理解这些因素如何参与此类过程，可以开发出针对性的治疗方法，并为垂体病变提供更好的未来管理方案。本文旨在总结肿瘤微环境各组成部分在垂体病变中的作用，同时评估它们与生物分子机制的关联。
