CC 趋化因子受体 5（CCR5）与调节性 T 细胞的联合预测了缺血性脑卒中患者的预后。
The combination of CC chemokine receptor type 5(CCR5) and Treg cells predicts prognosis in patients with ischemic stroke.
机构信息
Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Department of Anesthesiology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Wuxi Medical School, Jiangnan University, Wuxi, China.
出版信息
J Neuroimmunol. 2020 Dec 15;349:577404. doi: 10.1016/j.jneuroim.2020.577404. Epub 2020 Sep 24.
OBJECTIVE
Regulatory T cells (Tregs) play an important role in T cells. CC chemokine receptor 5 is a highly expressed chemokine receptor in T cells. They play an important role in inflammation and immune response of stroke.
METHODS
Flow cytometry measured Tregs and CCR5+ Tregs in the blood of patients. Univariate and multivariate logistic regression analysis were utilized to analyze the effect of Tregs and CCR5+ Tregs on the prognosis of ischemic stroke. Receiver operating characteristic (ROC) curve was used to assess predictive values for Treg cells and CCR5+ Tregs.
RESULTS
Tregs in patients with severe ischemic stroke were higher than those in mild ischemic stroke (P < 0.05), while the expression of CCR5+ Tregs were reversed (P < 0.05). The results of univariate and multivariate logistics regression analysis showed that Tregs and CCR5+ Tregs had a good predictive effect on the prognosis of ischemic stroke. The ROC curve demonstrated that the combination of Tregs and CCR+ Tregs achieved a better prediction effect (AUC = 0.758; P < 0.001).
CONCLUSIONS
The combination of Tregs and CCR5+ Tregs can be used as biomarkers for the prognosis of ischemic stroke.
目的
调节性 T 细胞（Tregs）在 T 细胞中发挥重要作用。CC 趋化因子受体 5 是 T 细胞中高表达的趋化因子受体。它们在中风的炎症和免疫反应中发挥重要作用。
方法
采用流式细胞术检测患者血液中的 Tregs 和 CCR5+Tregs。采用单因素和多因素 logistic 回归分析 Tregs 和 CCR5+Tregs 对缺血性中风预后的影响。采用接收者操作特征（ROC）曲线评估 Treg 细胞和 CCR5+Treg 细胞的预测价值。
结果
严重缺血性中风患者的 Tregs 高于轻度缺血性中风患者（P<0.05），而 CCR5+Tregs 的表达则相反（P<0.05）。单因素和多因素逻辑回归分析结果表明，Tregs 和 CCR5+Tregs 对缺血性中风的预后具有良好的预测作用。ROC 曲线表明 Tregs 和 CCR+Tregs 的联合具有更好的预测效果（AUC=0.758；P<0.001）。
结论
Tregs 和 CCR5+Tregs 的联合可作为缺血性中风预后的生物标志物。
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