Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Department of Anesthesiology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Wuxi Medical School, Jiangnan University, Wuxi, China.
J Neuroimmunol. 2020 Dec 15;349:577404. doi: 10.1016/j.jneuroim.2020.577404. Epub 2020 Sep 24.
Regulatory T cells (Tregs) play an important role in T cells. CC chemokine receptor 5 is a highly expressed chemokine receptor in T cells. They play an important role in inflammation and immune response of stroke.
Flow cytometry measured Tregs and CCR5+ Tregs in the blood of patients. Univariate and multivariate logistic regression analysis were utilized to analyze the effect of Tregs and CCR5+ Tregs on the prognosis of ischemic stroke. Receiver operating characteristic (ROC) curve was used to assess predictive values for Treg cells and CCR5+ Tregs.
Tregs in patients with severe ischemic stroke were higher than those in mild ischemic stroke (P < 0.05), while the expression of CCR5+ Tregs were reversed (P < 0.05). The results of univariate and multivariate logistics regression analysis showed that Tregs and CCR5+ Tregs had a good predictive effect on the prognosis of ischemic stroke. The ROC curve demonstrated that the combination of Tregs and CCR+ Tregs achieved a better prediction effect (AUC = 0.758; P < 0.001).
The combination of Tregs and CCR5+ Tregs can be used as biomarkers for the prognosis of ischemic stroke.
调节性 T 细胞（Tregs）在 T 细胞中发挥重要作用。CC 趋化因子受体 5 是 T 细胞中高表达的趋化因子受体。它们在中风的炎症和免疫反应中发挥重要作用。
采用流式细胞术检测患者血液中的 Tregs 和 CCR5+Tregs。采用单因素和多因素 logistic 回归分析 Tregs 和 CCR5+Tregs 对缺血性中风预后的影响。采用接收者操作特征（ROC）曲线评估 Treg 细胞和 CCR5+Treg 细胞的预测价值。
严重缺血性中风患者的 Tregs 高于轻度缺血性中风患者（P<0.05），而 CCR5+Tregs 的表达则相反（P<0.05）。单因素和多因素逻辑回归分析结果表明，Tregs 和 CCR5+Tregs 对缺血性中风的预后具有良好的预测作用。ROC 曲线表明 Tregs 和 CCR+Tregs 的联合具有更好的预测效果（AUC=0.758；P<0.001）。
Tregs 和 CCR5+Tregs 的联合可作为缺血性中风预后的生物标志物。
