Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Blegdamsvej 9, University of Copenhagen, Denmark.
Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Blegdamsvej 9, University of Copenhagen, Denmark.
Oral Oncol. 2020 Dec;111:105031. doi: 10.1016/j.oraloncology.2020.105031. Epub 2020 Oct 14.
Human papillomavirus infection and p16-overexpression is a principal cause and favorable prognostic factor for oropharyngeal squamous cell carcinomas but the value as prognostic marker in oral cavity squamous cell carcinomas (OSCC) is undetermined.
All patients diagnosed with OSCC in Eastern Denmark in the period 2008-2014 were enrolled. Survival estimates were evaluated as overall survival (OS) and progression free survival (PFS) by Kaplan-Meier survival curves and multivariate Cox-regression analyses.
We included 575 patients from which 13% (n = 69) had p16-positive tumors. The 5-year OS were 55% and 62% for the p16-negative and p16-positive patients, respectively, and the 5-year PFS were 48% and 50%. In a multivariate survival analysis, p16-positivity showed no significant influence on OS (HR: 1.06 [0.67-1.70], p = 0.79) and PFS (HR: 1.11 [0.76-1.63], p = 0.58).
In this population-based cohort of non-selected OSCC patients, we found no difference in survival outcomes when stratified on p16-overexpression status.
人乳头瘤病毒感染和 p16 过表达是口咽鳞状细胞癌的主要病因和有利的预后因素，但作为口腔鳞状细胞癌（OSCC）的预后标志物的价值尚未确定。
在 2008 年至 2014 年期间，丹麦东部所有被诊断为 OSCC 的患者均被纳入本研究。通过 Kaplan-Meier 生存曲线和多变量 Cox 回归分析评估生存估计值，包括总体生存率（OS）和无进展生存率（PFS）。
我们纳入了 575 名患者，其中 13%（n=69）的患者肿瘤 p16 阳性。p16 阴性和 p16 阳性患者的 5 年 OS 分别为 55%和 62%，5 年 PFS 分别为 48%和 50%。在多变量生存分析中，p16 阳性对 OS（HR：1.06 [0.67-1.70]，p=0.79）和 PFS（HR：1.11 [0.76-1.63]，p=0.58）均无显著影响。
在本基于人群的非选择性 OSCC 患者队列中，根据 p16 过表达状态分层，我们未发现生存结局存在差异。
