Kritpracha Chayanit, Leelasawatsuk Peesit, Kirtsreesakul Virat, Supanimitjaroenporn Pasawat, Tantipisit Jarukit, Tangthongkum Manupol
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai 90110, Songkhla, Thailand.
Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai 90110, Songkhla, Thailand.
Viruses. 2025 May 29;17(6):780. doi: 10.3390/v17060780.
An increasing number of patients are being diagnosed with tongue cancer despite lacking traditional risk factors such as tobacco, alcohol, or betel nut use. The potential role of human papillomavirus (HPV) in these cases has drawn attention, although its prognostic significance remains unclear. This retrospective cohort study, conducted in Southern Thailand, aimed to investigate the association between HPV status and overall survival in tongue cancer. Medical records of 186 patients treated between 2012 and 2021 were reviewed. HPV status was determined, and patients were categorized into HPV-negative, HPV-positive with other risk factors, and HPV-positive without known behavioral risk factors. Survival outcomes were compared using the log-rank test, and independent prognostic factors were analyzed using multivariable Cox regression. The overall prevalence of HPV infection was 9.6%, predominantly HPV16, HPV33, and HPV18. Although no significant differences were observed in 3-year overall survival, disease-specific survival, or recurrence-free survival among the groups, multivariable analysis revealed that HPV-positive patients without known behavioral risk factors (tobacco, alcohol, or betel nut use) had poorer overall survival (hazard ratio 3.54, = 0.045). The observed associations warrant further research into the prognostic role of HPV in tongue cancer among non-smoking, non-drinking populations.
尽管缺乏烟草、酒精或槟榔使用等传统风险因素，但被诊断为舌癌的患者数量仍在增加。人乳头瘤病毒（HPV）在这些病例中的潜在作用已引起关注，但其预后意义仍不清楚。这项在泰国南部进行的回顾性队列研究旨在调查HPV状态与舌癌总生存率之间的关联。回顾了2012年至2021年期间接受治疗的186例患者的病历。确定了HPV状态，并将患者分为HPV阴性、伴有其他风险因素的HPV阳性以及无已知行为风险因素的HPV阳性。使用对数秩检验比较生存结果，并使用多变量Cox回归分析独立预后因素。HPV感染的总体患病率为9.6%，主要为HPV16、HPV33和HPV18。尽管各组之间在3年总生存率、疾病特异性生存率或无复发生存率方面未观察到显著差异，但多变量分析显示，无已知行为风险因素（烟草、酒精或槟榔使用）的HPV阳性患者总生存率较差（风险比3.54，P = 0.045）。观察到的关联值得进一步研究HPV在不吸烟、不饮酒人群舌癌中的预后作用。
