Berliner G B
Ter Arkh. 1987;59(6):136-8.
The paper is concerned with a case of Brill-Symmers' disease started with the thrombocytopenic syndrome relating to hypersplenism. After splenectomy the first benign stage of disease without eradication therapy lasted over 10 years. Signs of immunological incompetence (signs of secondary infection) and recurring immune thrombocytopenia were noted in that period. A regular use of glucocorticoids and antibiotics resulted in the improved condition. The development of the second stage of disease (malignant diffuse lymphoma with the involvement of the internal organs) was fast resulting in the patient's death.
本文关注一例始于与脾功能亢进相关的血小板减少综合征的布里尔-西默斯病。脾切除术后，疾病的首个良性阶段在未进行根除治疗的情况下持续了10多年。在此期间，观察到免疫功能不全的迹象（继发感染迹象）和复发性免疫性血小板减少。定期使用糖皮质激素和抗生素使病情得到改善。疾病第二阶段（累及内脏的恶性弥漫性淋巴瘤）发展迅速，导致患者死亡。
