[中国成年人维生素D缺乏界值的探索性研究]

[Exploring study on the cutoff of vitamin D deficiency in Chinese adults].

作者信息

Hu Yichun, Li Siran, Liu Zhen, Yang Xiaoguang, Yang Lichen

机构信息

Key Laboratory of Trace Element Nutrition NHFPC, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

出版信息

Wei Sheng Yan Jiu. 2020 Sep;49(5):699-704. doi: 10.19813/j.cnki.weishengyanjiu.2020.05.001.

DOI:10.19813/j.cnki.weishengyanjiu.2020.05.001

PMID:33070813

Abstract

OBJECTIVE

To study the relationship between 25-hydroxyvitamin D [25(OH)D] concentration and intact parathyroid hormone(iPTH) concentration in the Chinese non-clinical population aged 18-44 y, and to explore the threshold value of determining the appropriate nutritional status of vitamin D.

METHODS

A total of 650 plasma samples of adults aged 18-44 years old were selected from the established biological samples' bank of Chinese Chronic Diseases and Nutrition Survey(CCDNS, 2015-2018). Basic information(including age, gender, region type, season, etc. ) was collected by questionnaires, and the waist circumference, height and weight of the subjects were determined unified. North and South area was divided by Qinling Mountains and Huaihe River. The serum 25(OH)D concentration was determined by high performance liquid chromatography tandem mass spectrometer, and the iPTH was determined by electronic chemiluminescence method. The relationship of 25(OH)D and iPTH were analyzed by partial correlation analysis, and the threshold of 25(OH)D was analyzed by locally weighted scatter plot smoothing method after adjusting the iPTH by age, season of blood draw, BMI, waist, sex and latitude.

RESULTS

A total of 623 serum samples(293 male, 330 female) of 25(OH)D concentration and iPTH concentration were analyzed after excluding samples with poor blood sample quality. Significant higher 25(OH)D concentration was found in male than female(P<0. 0001). And the samples from the southern China had higher 25(OH)D concentration than those from the northern China(P<0. 0001). Samples from autumn had higher 25(OH)D concentration than those from spring and winter(P<0. 0001). The 25(OH)D concentration of samples from cities was lower than that of rural areas(P=0. 018). The inversely relationship between 25(OH)D concentration and iPTH concentration was observed when the 25(OH)D was below 17. 6 ng/mL for both sexes. The threshold of 25(OH)D for male was 16. 2 ng/mL and it was 25. 6 ng/mL for female.

CONCLUSION

The threshold and the relationship between 25(OH)D and iPTH differs by sex among Chinese adults aged 18-44 y. Further study is needed to evaluate the sex-specific ranges of optimal vitamin D.

摘要

目的

研究中国18 - 44岁非临床人群中25 - 羟基维生素D[25(OH)D]浓度与全段甲状旁腺激素(iPTH)浓度之间的关系，并探索确定维生素D适宜营养状态的阈值。

方法

从中国慢性病与营养调查（CCDNS，2015 - 2018年）已建立的生物样本库中选取650份18 - 44岁成年人的血浆样本。通过问卷调查收集基本信息（包括年龄、性别、地区类型、季节等），并统一测定受试者的腰围、身高和体重。以秦岭淮河为界划分南北区域。采用高效液相色谱串联质谱仪测定血清25(OH)D浓度，采用电化学发光法测定iPTH。通过偏相关分析分析25(OH)D与iPTH的关系，并在对年龄、采血季节、BMI、腰围、性别和纬度调整iPTH后，采用局部加权散点图平滑法分析25(OH)D的阈值。

结果

排除血样质量差的样本后，共分析了623份25(OH)D浓度和iPTH浓度的血清样本（男性293份，女性330份）。发现男性的25(OH)D浓度显著高于女性（P<0.0001）。来自中国南方的样本25(OH)D浓度高于北方的样本（P<0.0001）。秋季样本的25(OH)D浓度高于春季和冬季的样本（P<0.0001）。城市样本的25(OH)D浓度低于农村样本（P = 0.018）。当25(OH)D低于17.6 ng/mL时，男女的25(OH)D浓度与iPTH浓度均呈负相关。男性的25(OH)D阈值为16.2 ng/mL，女性为25.6 ng/mL。