Bai Kai, Dong Heng, Liu Ling, She Xuhui, Liu Chang, Yu Mujun, Liang Zhihui, Lin Haibiao, Ke Peifeng, Huang Xianzhang, Wu Xinzhong, Zhang Qiaoxuan, Zhao Beibei
Department of Laboratory Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, 510120, China.
Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
Eur J Nutr. 2023 Apr;62(3):1503-1516. doi: 10.1007/s00394-023-03094-z. Epub 2023 Jan 24.
We aimed to describe the vitamin D status and its distribution in different age groups, sexes, seasons, and provinces of a large Chinese population.
This study retrospectively analyzed 1,528,685 results of serum 25-hydroxyvitamin D (25(OH)D) in the central laboratory of KingMed Diagnostics. The samples were from the individuals aged 0-119 years old in 30 provinces of China. Serum 25(OH)D was measured by an accurate commercial liquid chromatography-tandem mass spectrometry (LC-MS/MS) method from January 2017 to December 2019. The subjects were stratified by age, sex, the season of blood collection, and the province of residence.
The median 25(OH)D concentration was 25.5 ng/mL (interquartile range (IQR) 18.7-32.7 ng/mL) in males and 20.8 ng/mL (IQR 14.4-28.2 ng/mL) in females. Overall, the median 25(OH)D concentration decreased with age in both males and females. Males had a 0.2-2.4 ng/mL higher median 25(OH)D concentration than females in different age groups. Vitamin D deficiency (25(OH)D < 15 ng/mL for the individuals under 14 years old; < 20 ng/mL for the individuals over 14 years old) was found in 21.3% of males and 43.6% of females. Significant seasonal variation of serum 25(OH)D concentrations was repeatedly observed in 3 years, with median concentration higher in summer (25.3 ng/mL (IQR 19.3-31.9 ng/mL)) and lower in winter (18.5 ng/mL (IQR 12.3-26.6 ng/mL)). Vitamin D status varied by province. The median 25(OH)D concentration was the highest in Hainan (31.0 ng/mL (IQR 24.9-39.2 ng/mL)) and the lowest in Qinghai (14.4 ng/mL (IQR 9.6-20.0 ng/mL)). 25(OH)D was detected in 12.2% of the results, and no significant seasonal variation was observed.
In China, vitamin D deficiency is prevalent in the population participating in clinical vitamin D measurement. Age and sex differences in vitamin D levels were observed in our study. Seasonal variation and provincial differences are important aspects of serum vitamin D status. 25(OH)D cannot be ignored entirely in clinical measurement practice in China.
我们旨在描述中国一大群人的维生素D状况及其在不同年龄组、性别、季节和省份的分布情况。
本研究回顾性分析了金域检验中心实验室1528685例血清25-羟维生素D（25(OH)D）检测结果。样本来自中国30个省份0至119岁的个体。2017年1月至2019年12月期间，采用精确的商业液相色谱-串联质谱法（LC-MS/MS）测定血清25(OH)D。研究对象按年龄、性别、采血季节和居住省份进行分层。
男性25(OH)D浓度中位数为25.5 ng/mL（四分位间距（IQR）18.7 - 32.7 ng/mL），女性为20.8 ng/mL（IQR 14.4 - 28.2 ng/mL）。总体而言，男性和女性的25(OH)D浓度中位数均随年龄增长而降低。在不同年龄组中，男性的25(OH)D浓度中位数比女性高0.2 - 2.4 ng/mL。维生素D缺乏（14岁以下个体25(OH)D＜15 ng/mL；14岁以上个体＜20 ng/mL）在21.3%的男性和43.6%的女性中被发现。在3年中反复观察到血清25(OH)D浓度存在显著的季节性变化，夏季中位数浓度较高（25.3 ng/mL（IQR 19.3 - 31.9 ng/mL）），冬季较低（18.5 ng/mL（IQR 12.3 - 26.6 ng/mL））。维生素D状况因省份而异。25(OH)D浓度中位数在海南最高（31.0 ng/mL（IQR 24.9 - 39.2 ng/mL）），在青海最低（14.4 ng/mL（IQR 9.6 - 20.0 ng/mL））。在12.2%的检测结果中检测到25(OH)D，且未观察到显著的季节性变化。
在中国，参与临床维生素D检测的人群中维生素D缺乏普遍存在。我们的研究观察到了维生素D水平的年龄和性别差异。季节性变化和省份差异是血清维生素D状况的重要方面。在中国的临床检测实践中，25(OH)D也不能被完全忽视。
