Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia.
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Am J Emerg Med. 2021 Aug;46:204-211. doi: 10.1016/j.ajem.2020.07.009. Epub 2020 Jul 9.
Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease.
In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19.
We performed a systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and medRxiv with the search terms, "Heart failure" and "COVID-19". The outcome of interest was mortality and poor prognosis (defined by incidence of severe COVID-19 infection, admission to ICU, and use of ventilator) in patients with preexisting heart failure with coronavirus disease.
We identified 204 potential articles from our search, and 22 duplicates were removed. After screening of the titles and abstracts of the remaining 182 articles we identified 92 potentially relevant articles. We excluded 74 studies due to the following reasons: four studies were systematic reviews, two studies were meta-analyses, three articles were literature reviews, and 65 articles did not report on the outcome of interest. Finally, we included the remaining 18 studies in our qualitative synthesis and meta-analysis. There were 21,640 patients from 18 studies. HF was associated with hospitalization in COVID19 HR was 2.37 [1.48, 3.79; p < 0.001], high heterogeneity [I, 82%; p < 0.001]. HF was associated with a poor outcome demonstrated by an OR of 2.86 [2.07; 3.95; p < 0.001] high heterogeneity [I, 80%; p < 0.001]. Patient with preexisting HF was associated with higher mortality OR of 3.46 [2.52, 4.75; p < 0.001] moderately high heterogeneity [I, 77%; p < 0.001].
Patients with heart failure are at increased risk for hospitalization, poor outcome, and death from COVID-19. A significant difference in mortality between patients with and without heart failure was observed, patients with heart failure having a higher mortality.
多种合并症与 2019 年冠状病毒病（COVID-19）的严重程度和死亡率增加有关，包括高血压、糖尿病、脑血管疾病、慢性肾脏病和慢性阻塞性肺疾病。
在这项系统评价和荟萃分析中，我们试图研究心力衰竭（HF）与 COVID-19 患者不良结局之间的关系。
我们使用“心力衰竭”和“COVID-19”等检索词，从 PubMed、EuropePMC、SCOPUS、Cochrane 中央数据库和 medRxiv 进行了系统文献检索。我们感兴趣的结局是心力衰竭患者的死亡率和不良预后（通过严重 COVID-19 感染、入住 ICU 和使用呼吸机的发生率来定义）。
我们从检索中确定了 204 篇潜在文章，排除了 22 篇重复文章。在筛选其余 182 篇文章的标题和摘要后，我们确定了 92 篇潜在相关文章。我们排除了 74 项研究，原因如下：四项研究为系统评价，两项研究为荟萃分析，三篇文章为文献综述，65 篇文章未报告我们感兴趣的结局。最后，我们对其余 18 项研究进行了定性综合和荟萃分析。18 项研究共有 21640 名患者。心力衰竭与 COVID19 住院相关 HR 为 2.37 [1.48, 3.79;p<0.001]，存在高度异质性[I, 82%;p<0.001]。心力衰竭与不良结局相关，OR 为 2.86 [2.07; 3.95;p<0.001]，存在高度异质性[I, 80%;p<0.001]。患有心力衰竭的患者与更高的死亡率相关 OR 为 3.46 [2.52, 4.75;p<0.001]，存在中度高度异质性[I, 77%;p<0.001]。
心力衰竭患者住院、不良结局和 COVID-19 死亡的风险增加。观察到心力衰竭患者与无心力衰竭患者之间的死亡率存在显著差异，心力衰竭患者的死亡率更高。
