Bodea Réka, Voidăzan Toader Septimiu, Ferencz Lorand Iozsef, Ábrám Zoltán
Department of Epidemiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mureș, 540142 Târgu Mureș, Romania.
Department of Hygiene, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mureș, 540142 Târgu Mureș, Romania.
Microorganisms. 2025 Mar 29;13(4):787. doi: 10.3390/microorganisms13040787.
The COVID-19 pandemic represents a major global health crisis, with clinical manifestations ranging from asymptomatic infection to fatal outcomes. While all individuals are susceptible, specific populations, particularly those with pre-existing medical conditions, face a heightened risk of severe disease. This study aimed to assess the prevalence of severe COVID-19 among hospitalized patients with comorbidities in the Central Region of Romania, and to analyze the association between these conditions and mortality. We conducted a retrospective cohort study using data from the Corona Forms platform (2020-2022), encompassing hospitalized cases across three Romanian counties. A total of 1458 patients with confirmed SARS-CoV-2 infection and documented comorbidities were included. Demographic characteristics, comorbid conditions, and hospitalization outcomes were analyzed. The overall mortality rate among comorbid patients was 89.3%. Renal, neurologic, hepatic disease, cardiovascular conditions, obesity, type 2 diabetes mellitus, and cerebrovascular accidents are significant risk factors for death outcomes in the SARS-CoV-2-infected study population. The strength of their association varies, with odds ratios ranging from 25.32 to 1. The findings underscore the critical impact of comorbidities on COVID-19 severity and mortality among the Central Romanian population, emphasizing the necessity of targeted clinical interventions and public health strategies to protect high-risk populations.
新冠疫情是一场重大的全球卫生危机，其临床表现从无症状感染到致命后果不等。虽然所有人都易感染，但特定人群，尤其是那些有基础疾病的人群，面临着更高的重症风险。本研究旨在评估罗马尼亚中部地区合并症住院患者中重症新冠肺炎的患病率，并分析这些疾病与死亡率之间的关联。我们利用来自Corona Forms平台（2020 - 2022年）的数据进行了一项回顾性队列研究，涵盖罗马尼亚三个县的住院病例。总共纳入了1458例确诊感染SARS-CoV-2且有合并症记录的患者。分析了人口统计学特征、合并症情况和住院结局。合并症患者的总体死亡率为89.3%。肾脏疾病、神经系统疾病、肝脏疾病、心血管疾病、肥胖症、2型糖尿病和脑血管意外是SARS-CoV-2感染研究人群死亡结局的重要危险因素。它们之间关联的强度各不相同，比值比范围从25.32到1。研究结果强调了合并症对罗马尼亚中部人群新冠肺炎严重程度和死亡率的关键影响，强调了采取针对性临床干预措施和公共卫生策略以保护高危人群的必要性。
