Olusanya A A, Michael A I, Olawoye O A, Akinmoladun V I
Department of Oral and Maxillofacial Surgery, College of Medicine, University of Ibadan, Nigeria.
Department of Plastic, Reconstructive and Aesthetic Surgery, University College Hospital, Ibadan.
Ann Ib Postgrad Med. 2020 Jun;18(1):S2-S8.
Exogenous factors occurring in the antenatal period could be contributory to the formation of orofacial cleft. This study sought to determine the antenatal events in mothers that may have contributed to orofacial cleft deformity of their children.
It was a prospective observational cross sectional study of consenting mothers of babies with orofacial cleft who met the inclusion criteria. The study instrument was a questionnaire.
Seventy-two mothers participated in the study. Most of these mothers were below 35 years of age and more than half, 43 (59.7%) were of the low-intermediate socioeconomic status. Although majority, 70 (97.2) of the mothers had antenatal care, the mean gestational age at commencement of antenatal care was 4 months. Almost all, 69 (95.8%) mothers had ultrasound scans however the detection of the orofacial cleft was in only 2 (2.8%) mothers. The commonest medication taken was haematinics, 26 (36.1%). Herbal medication, 15 (20.8%) and antimalarial, 12 (16.7%) were the other drugs more frequently taken. The mean age of pregnancy at commencement of these medications was 3.6 months.
Although uptake of antenatal service was common practice among mothers of babies with orofacial clefts in this study, no antenatal predisposing factors were identified.
孕期出现的外部因素可能导致口面部裂隙的形成。本研究旨在确定母亲孕期中可能导致其子女口面部裂隙畸形的事件。
这是一项对符合纳入标准的口面部裂隙患儿母亲进行的前瞻性观察性横断面研究。研究工具为一份问卷。
72位母亲参与了本研究。这些母亲大多年龄在35岁以下，其中超过半数，即43位（59.7%）处于中低社会经济地位。尽管大多数母亲，即70位（97.2%）接受了产前护理，但产前护理开始时的平均孕周为4个月。几乎所有母亲，即69位（95.8%）进行了超声检查，然而仅2位（2.8%）母亲的口面部裂隙被检测出。最常服用的药物是补血药，有26位（36.1%）。草药，15位（20.8%）和抗疟药，12位（16.7%）是其他较常服用的药物。这些药物开始服用时的平均怀孕年龄为3.6个月。
尽管在本研究中，接受产前服务在口面部裂隙患儿母亲中是常见做法，但未发现产前诱发因素。
