Chen Mingxian, Li Xuping, Wang Songyun, Yu Lilei, Tang Jianjun, Zhou Shenghua
The Second Xiangya Hospital, Central South University, Changsha, China.
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Front Physiol. 2020 Sep 23;11:1113. doi: 10.3389/fphys.2020.01113. eCollection 2020.
In the heart, cardiac macrophages have widespread biological functions, including roles in antigen presentation, phagocytosis, and immunoregulation, through the formation of diverse cytokines and growth factors; thus, these cells play an active role in tissue repair after heart injury. Recent clinical studies have indicated that macrophages or elevated inflammatory cytokines secreted by macrophages are closely related to ventricular arrhythmias (VAs). This review describes the role of macrophages and macrophage-secreted inflammatory cytokines in ventricular arrhythmogenesis.
在心脏中，心脏巨噬细胞具有广泛的生物学功能，包括通过形成多种细胞因子和生长因子在抗原呈递、吞噬作用和免疫调节中发挥作用；因此，这些细胞在心脏损伤后的组织修复中发挥积极作用。最近的临床研究表明，巨噬细胞或巨噬细胞分泌的炎症细胞因子升高与室性心律失常（VA）密切相关。这篇综述描述了巨噬细胞和巨噬细胞分泌的炎症细胞因子在室性心律失常发生中的作用。
