• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于局部癌症治疗的新兴技术。

Emerging technologies for local cancer treatment.

作者信息

Chua Corrine Ying Xuan, Ho Jeremy, Demaria Sandra, Ferrari Mauro, Grattoni Alessandro

机构信息

Department of Nanomedicine, Houston Methodist Research Institute (HMRI), Houston, TX, 77030, USA.

School of Medicine, Weill Cornell Medical College, Weill Cornell Medicine, New York, NY, 10065, USA.

出版信息

Adv Ther (Weinh). 2020 Sep;3(9). doi: 10.1002/adtp.202000027. Epub 2020 Jun 5.

DOI:10.1002/adtp.202000027
PMID:33072860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7567411/
Abstract

The fundamental limitations of systemic therapeutic administration have prompted the development of local drug delivery platforms as a solution to increase effectiveness and reduce side effects. By confining therapeutics to the site of disease, local delivery technologies can enhance therapeutic index. This review highlights recent advances and opportunities in local drug delivery strategies for cancer treatment in addition to challenges that need to be addressed to facilitate clinical translation. The benefits of local cancer treatment combined with technological advancements and increased understanding of the tumor microenvironment, present a prime breakthrough opportunity for safer and more effective therapies.

摘要

全身治疗给药的基本局限性促使了局部给药平台的发展，作为提高疗效和减少副作用的一种解决方案。通过将治疗药物局限于疾病部位，局部给药技术可以提高治疗指数。本综述重点介绍了癌症治疗局部给药策略的最新进展和机遇，以及为促进临床转化需要解决的挑战。局部癌症治疗的优势，结合技术进步和对肿瘤微环境的深入了解，为更安全、更有效的治疗提供了一个重大突破机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/2f6362d044c5/nihms-1624759-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/8e286744a173/nihms-1624759-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/40c3cdd649f1/nihms-1624759-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/651d019d90c6/nihms-1624759-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/d17d5145fec0/nihms-1624759-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/900add560c3e/nihms-1624759-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/2f6362d044c5/nihms-1624759-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/8e286744a173/nihms-1624759-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/40c3cdd649f1/nihms-1624759-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/651d019d90c6/nihms-1624759-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/d17d5145fec0/nihms-1624759-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/900add560c3e/nihms-1624759-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96cf/7567411/2f6362d044c5/nihms-1624759-f0006.jpg

相似文献

1
Emerging technologies for local cancer treatment.用于局部癌症治疗的新兴技术。
Adv Ther (Weinh). 2020 Sep;3(9). doi: 10.1002/adtp.202000027. Epub 2020 Jun 5.
2
Designing Hydrogels for On-Demand Therapy.设计按需治疗的水凝胶。
Acc Chem Res. 2017 Apr 18;50(4):669-679. doi: 10.1021/acs.accounts.6b00536. Epub 2017 Mar 16.
3
Microneedles for Efficient and Precise Drug Delivery in Cancer Therapy.用于癌症治疗中高效精准给药的微针
Pharmaceutics. 2023 Feb 23;15(3):744. doi: 10.3390/pharmaceutics15030744.
4
Complex Coacervates as a Promising Vehicle for mRNA Delivery: A Comprehensive Review of Recent Advances and Challenges.复杂凝聚体作为 mRNA 递送的有前途载体：最新进展和挑战的综合综述。
Mol Pharm. 2023 Sep 4;20(9):4387-4403. doi: 10.1021/acs.molpharmaceut.3c00439. Epub 2023 Aug 10.
5
Local co-administration of gene-silencing RNA and drugs in cancer therapy: State-of-the art and therapeutic potential.局部联合基因沉默 RNA 和药物治疗癌症：现状和治疗潜力。
Cancer Treat Rev. 2017 Apr;55:128-135. doi: 10.1016/j.ctrv.2017.03.004. Epub 2017 Mar 16.
6
Intratumoral therapies and in-situ vaccination for melanoma.肿瘤内治疗和原位疫苗接种治疗黑色素瘤。
Hum Vaccin Immunother. 2022 May 31;18(3):1890512. doi: 10.1080/21645515.2021.1890512.
7
Recent Studies and Progress in the Intratumoral Administration of Nano-Sized Drug Delivery Systems.纳米级药物递送系统瘤内给药的最新研究与进展
Nanomaterials (Basel). 2023 Jul 31;13(15):2225. doi: 10.3390/nano13152225.
8
How Various Drug Delivery Methods Could Aid in the Translation of Genome Prime Editing Technologies.各种药物输送方法如何有助于基因组原代编辑技术的转化。
Genet Res (Camb). 2022 Feb 21;2022:7301825. doi: 10.1155/2022/7301825. eCollection 2022.
9
Local scaffold-assisted delivery of immunotherapeutic agents for improved cancer immunotherapy.局部支架辅助递呈免疫治疗药物以改善癌症免疫治疗。
Adv Drug Deliv Rev. 2022 Jun;185:114308. doi: 10.1016/j.addr.2022.114308. Epub 2022 Apr 23.
10
Engineered in-situ depot-forming hydrogels for intratumoral drug delivery.用于肿瘤内药物输送的工程化原位形成储库水凝胶。
J Control Release. 2015 Dec 28;220(Pt A):465-475. doi: 10.1016/j.jconrel.2015.11.014. Epub 2015 Nov 14.

引用本文的文献

1
Challenges in the preclinical design and assessment of CAR-T cells.嵌合抗原受体T细胞（CAR-T细胞）临床前设计与评估中的挑战。
Front Immunol. 2025 Aug 8;16:1564998. doi: 10.3389/fimmu.2025.1564998. eCollection 2025.
2
Small molecular chelator for comprehensive regulation of tumor lactate levels in synergy with photodynamic therapy for cancer treatment.用于协同光动力疗法全面调节肿瘤乳酸水平以治疗癌症的小分子螯合剂。
Asian J Pharm Sci. 2025 Aug;20(4):101059. doi: 10.1016/j.ajps.2025.101059. Epub 2025 Apr 23.
3
Glucose-Fueled Gated Nanomotors: Enhancing Anticancer Efficacy via Deep Drug Penetration into Tumors.

本文引用的文献

1
Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.原位凝胶化后进行局部鸡尾酒化疗免疫疗法，以触发强大的全身抗肿瘤免疫反应。
Sci Adv. 2020 Mar 4;6(10):eaaz4204. doi: 10.1126/sciadv.aaz4204. eCollection 2020 Mar.
2
Bringing down the cost of cancer treatment.降低癌症治疗成本。
Nature. 2018 Mar;555(7695):S26-S29. doi: 10.1038/d41586-018-02483-3.
3
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges.利用纳米医学提高癌症免疫疗法的疗效：进展、机遇与挑战。
葡萄糖驱动的门控纳米马达：通过药物深入渗透肿瘤增强抗癌疗效
ACS Nano. 2025 Jun 10;19(22):20932-20955. doi: 10.1021/acsnano.5c03799. Epub 2025 May 30.
4
Ionizable lipid nanoparticles with functionalized PEG-lipids increase retention in the tumor microenvironment.具有功能化聚乙二醇脂质的可电离脂质纳米颗粒可增加在肿瘤微环境中的滞留时间。
Mol Ther Methods Clin Dev. 2025 Mar 27;33(2):101457. doi: 10.1016/j.omtm.2025.101457. eCollection 2025 Jun 12.
5
Acoustically Driven Hybrid Nanocrystals for In Vivo Pancreatic Cancer Treatment.用于体内胰腺癌治疗的声学驱动混合纳米晶体
ACS Appl Mater Interfaces. 2025 Feb 26;17(8):11873-11887. doi: 10.1021/acsami.4c21975. Epub 2025 Feb 17.
6
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade.替格来诺醇替格列酯是一种溶瘤小分子，可诱导免疫原性细胞死亡，并增强靶肿瘤和未注射肿瘤对免疫检查点阻断的反应。
J Immunother Cancer. 2024 Apr 24;12(4):e006602. doi: 10.1136/jitc-2022-006602.
7
Localized radiotherapy of solid tumors using radiopharmaceutical loaded implantable system: insights from a mathematical model.使用载有放射性药物的可植入系统对实体瘤进行局部放射治疗：来自数学模型的见解
Front Oncol. 2024 Feb 26;14:1320371. doi: 10.3389/fonc.2024.1320371. eCollection 2024.
8
Efficient chemo-immunotherapy leveraging minimalist electrostatic complex nanoparticle as "in situ" vaccine integrated tumor ICD and immunoagonist.利用极简静电复合纳米颗粒作为“原位”疫苗整合肿瘤免疫原性细胞死亡和免疫激动剂的高效化学免疫疗法。
J Adv Res. 2025 Mar;69:169-179. doi: 10.1016/j.jare.2024.03.010. Epub 2024 Mar 16.
9
Intratumoral Injection of Large Surface Area Microparticle Taxanes in Carcinomas Increases Immune Effector Cell Concentrations, Checkpoint Expression, and Synergy with Checkpoint Inhibitors: A Review of Preclinical and Clinical Studies.肿瘤内注射大表面积微粒紫杉烷类药物治疗癌症可增加免疫效应细胞浓度、检查点表达，并增强与检查点抑制剂的协同作用：临床前和临床研究综述
Oncol Ther. 2024 Mar;12(1):31-55. doi: 10.1007/s40487-024-00261-y. Epub 2024 Jan 30.
10
Exploring the Potential of Montmorillonite as an Antiproliferative Nanoagent against MDA-MB-231 and MCF-7 Human Breast Cancer Cells.探索蒙脱石作为抗MDA-MB-231和MCF-7人乳腺癌细胞增殖纳米剂的潜力。
Cells. 2024 Jan 22;13(2):200. doi: 10.3390/cells13020200.
Nat Rev Clin Oncol. 2020 Apr;17(4):251-266. doi: 10.1038/s41571-019-0308-z. Epub 2020 Feb 7.
4
Response and outcomes after anti-CTLA4 versus anti-PD1 combined with stereotactic body radiation therapy for metastatic non-small cell lung cancer: retrospective analysis of two single-institution prospective trials.抗 CTLA4 与抗 PD1 联合立体定向体部放疗治疗转移性非小细胞肺癌的反应和结果：两项单机构前瞻性试验的回顾性分析。
J Immunother Cancer. 2020 Jan;8(1). doi: 10.1136/jitc-2019-000492.
5
Phase II Trial of Ipilimumab with Stereotactic Radiation Therapy for Metastatic Disease: Outcomes, Toxicities, and Low-Dose Radiation-Related Abscopal Responses.立体定向放疗联合依匹单抗治疗转移性疾病的 II 期临床试验：结果、毒性和低剂量放射相关的远隔效应。
Cancer Immunol Res. 2019 Dec;7(12):1903-1909. doi: 10.1158/2326-6066.CIR-18-0793. Epub 2019 Oct 28.
6
Immunotoxicity Considerations for Next Generation Cancer Nanomedicines.下一代癌症纳米药物的免疫毒性考量
Adv Sci (Weinh). 2019 Aug 1;6(19):1900133. doi: 10.1002/advs.201900133. eCollection 2019 Oct 2.
7
Improving cancer immunotherapy through nanotechnology.通过纳米技术提高癌症免疫疗法。
Nat Rev Cancer. 2019 Oct;19(10):587-602. doi: 10.1038/s41568-019-0186-9. Epub 2019 Sep 6.
8
Assessing the interactions between radiotherapy and antitumour immunity.评估放疗与抗肿瘤免疫的相互作用。
Nat Rev Clin Oncol. 2019 Dec;16(12):729-745. doi: 10.1038/s41571-019-0238-9. Epub 2019 Jun 26.
9
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy.瘤内给予细胞因子锚定在胶原上安全增强了系统癌症免疫治疗。
Sci Transl Med. 2019 Jun 26;11(498). doi: 10.1126/scitranslmed.aaw2614.
10
Recent advances in intraocular sustained-release drug delivery devices.近期眼内缓释药物输送装置的进展。
Drug Discov Today. 2019 Aug;24(8):1694-1700. doi: 10.1016/j.drudis.2019.05.031. Epub 2019 Jun 4.