用于局部癌症治疗的新兴技术。
Emerging technologies for local cancer treatment.
作者信息
Chua Corrine Ying Xuan, Ho Jeremy, Demaria Sandra, Ferrari Mauro, Grattoni Alessandro
机构信息
Department of Nanomedicine, Houston Methodist Research Institute (HMRI), Houston, TX, 77030, USA.
School of Medicine, Weill Cornell Medical College, Weill Cornell Medicine, New York, NY, 10065, USA.
出版信息
Adv Ther (Weinh). 2020 Sep;3(9). doi: 10.1002/adtp.202000027. Epub 2020 Jun 5.
Abstract
The fundamental limitations of systemic therapeutic administration have prompted the development of local drug delivery platforms as a solution to increase effectiveness and reduce side effects. By confining therapeutics to the site of disease, local delivery technologies can enhance therapeutic index. This review highlights recent advances and opportunities in local drug delivery strategies for cancer treatment in addition to challenges that need to be addressed to facilitate clinical translation. The benefits of local cancer treatment combined with technological advancements and increased understanding of the tumor microenvironment, present a prime breakthrough opportunity for safer and more effective therapies.
摘要
全身治疗给药的基本局限性促使了局部给药平台的发展，作为提高疗效和减少副作用的一种解决方案。通过将治疗药物局限于疾病部位，局部给药技术可以提高治疗指数。本综述重点介绍了癌症治疗局部给药策略的最新进展和机遇，以及为促进临床转化需要解决的挑战。局部癌症治疗的优势，结合技术进步和对肿瘤微环境的深入了解，为更安全、更有效的治疗提供了一个重大突破机会。
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