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一锅法平行合成未封闭穴状配体——通过静态组合化学技术寻找选择性阴离子受体

One-Pot Parallel Synthesis of Unclosed Cryptands-Searching for Selective Anion Receptors via Static Combinatorial Chemistry Techniques.

作者信息

Niedbała Patryk, Jurczak Janusz

机构信息

Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.

出版信息

ACS Omega. 2020 Sep 30;5(40):26271-26277. doi: 10.1021/acsomega.0c04228. eCollection 2020 Oct 13.

DOI:10.1021/acsomega.0c04228
PMID:33073154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7558039/
Abstract

We present the synthesis of 17 macrocyclic compounds having the structure of so-called unclosed cryptands, acting as anion receptors. These compounds possess amide functions playing the role of hydrogen-bond-donating systems. We have synthesized the presented compounds both by standard methods (using batch conditions) and by static combinatorial chemistry methods, using tetrabutylammonium dihydrogen phosphate as a template, promoting the lariat arm postfunctionalization reaction.

摘要

我们展示了17种具有所谓未封闭穴状配体结构的大环化合物的合成，这些化合物可作为阴离子受体。这些化合物具有酰胺官能团，起到氢键供体系统的作用。我们通过标准方法（使用间歇条件）和静态组合化学方法合成了这些化合物，以磷酸二氢四丁铵作为模板促进套索臂后官能化反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/6e4b9257d54f/ao0c04228_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/595b2ca2431a/ao0c04228_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/7c68832f2333/ao0c04228_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/528a4cd87490/ao0c04228_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/f916fed92147/ao0c04228_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/3f385463dd04/ao0c04228_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/e35c01f72ead/ao0c04228_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/cca5b4e6a208/ao0c04228_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/6e4b9257d54f/ao0c04228_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/595b2ca2431a/ao0c04228_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/7c68832f2333/ao0c04228_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/528a4cd87490/ao0c04228_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/f916fed92147/ao0c04228_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/3f385463dd04/ao0c04228_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/e35c01f72ead/ao0c04228_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/cca5b4e6a208/ao0c04228_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b75/7558039/6e4b9257d54f/ao0c04228_0009.jpg

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Anthracene-Based Amido-Amine Cage Receptor for Anion Recognition under Neutral Aqueous Conditions.基于蒽的酰胺-胺笼受体在中性水条件下对阴离子的识别。
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