血红素/血红素加氧酶-1系统是对伴有严重并发症的新冠肺炎患者的一种潜在治疗干预措施。
Heme/Hemeoxygenase-1 System Is a Potential Therapeutic Intervention for COVID-19 Patients with Severe Complications.
作者信息
Maiti Biplab K
机构信息
National Institute of Technology Sikkim, Ravangla Campus, Barfung Block, Ravangla Sub Division, South Sikkim 737139, India.
出版信息
ACS Pharmacol Transl Sci. 2020 Sep 28;3(5):1032-1034. doi: 10.1021/acsptsci.0c00136. eCollection 2020 Oct 9.
Abstract
Acute respiratory distress syndrome (ARDS) is one of the critical stages of COVID-19, leading to lung injury and hemolysis. Dysfunctional hemoglobin (Hb) suffers low-level oxygenation, overloaded iron, and down-regulation of hemeoxygenase-1 (HO-1), representing potential therapeutic interventions. This Viewpoint outlines the Hb-HO-1 system as a host-cell target, and proposes possible therapies, including iron chelation and CO therapies, against COVID-19 with ARDS.
摘要
急性呼吸窘迫综合征（ARDS）是新型冠状病毒肺炎（COVID-19）的关键阶段之一，可导致肺损伤和溶血。功能失调的血红蛋白（Hb）存在低水平氧合、铁过载以及血红素加氧酶-1（HO-1）下调等情况，这些表现代表了潜在的治疗干预靶点。本观点将Hb-HO-1系统概述为宿主细胞靶点，并提出了针对伴有ARDS的COVID-19的可能治疗方法，包括铁螯合疗法和一氧化碳（CO）疗法。
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