Department of Anesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Drugs Aging. 2020 Dec;37(12):863-874. doi: 10.1007/s40266-020-00803-9. Epub 2020 Oct 19.
The number of older patients is increasing globally. Combined with the growing number of ambulatory surgeries, many older patients will undergo ambulatory surgery in the future. The ambulatory setting offers many advantages: early mobilization, higher patient satisfaction, lower costs, and a low incidence of several complications such as infections and thromboembolic events. Moreover, cognitive recovery seems to be enhanced compared with in-hospital surgery, and both frail patients and patients with dementia can benefit from ambulatory surgery. This review provides suggestions for managing perioperative anesthesia for older patients in the ambulatory setting. Not all older patients are eligible for ambulatory surgery, and clinicians must be aware of risk factors for complications, especially frailty. Most anesthesia techniques and agents can be used in the ambulatory setting, but short-acting agents are preferred to ensure fast recovery. Both regional and general anesthesia are useful, but clinicians must be familiar with the physiological changes and specific implications in the older population. The older patients are more sensitive to anesthetic agents, meaning that a lower dose is needed to obtain the desired effect. However, they exhibit huge variation in pharmacodynamics and pharmacokinetics. Prolonged onset time may lead to overdosing and extended recovery. After surgery, effective pain management with opioid minimization is essential to ensure rapid recovery.
全球老年患者人数不断增加。再加上日间手术数量的不断增加,未来许多老年患者将接受日间手术。日间手术有许多优点:早期活动、更高的患者满意度、更低的成本以及降低几种并发症(如感染和血栓栓塞事件)的发生率。此外,与住院手术相比,认知恢复似乎增强了,体弱患者和痴呆患者都可以从日间手术中受益。这篇综述为管理在日间手术环境下的老年患者围手术期麻醉提供了建议。并非所有老年患者都适合日间手术,临床医生必须了解并发症的风险因素,特别是体弱。大多数麻醉技术和药物都可用于日间手术,但为了确保快速恢复,首选短效药物。区域麻醉和全身麻醉都很有用,但临床医生必须熟悉老年人的生理变化和具体影响。老年患者对麻醉药物更敏感,这意味着需要较低剂量才能达到预期效果。然而,他们在药效学和药代动力学方面存在巨大差异。起效时间延长可能导致药物过量和恢复延长。手术后,有效镇痛和最小化阿片类药物的使用对于确保快速恢复至关重要。