Faculty of Medicine, University of Toronto, Toronto, Canada.
Department of Family and Community Medicine, University of Toronto, Toronto, Canada.
Top Stroke Rehabil. 2021 Sep;28(6):475-480. doi: 10.1080/10749357.2020.1834274. Epub 2020 Oct 17.
Persistent and intractable hiccups have a major impact on quality of life and can be a barrier to stroke rehabilitation. The first-line treatment for intractable hiccups, chlorpromazine, can have sedating effects, which may negatively affect rehabilitation participation. Gabapentin has been reported in several cases to be effective in hiccup treatment in both the general and post-stroke populations.
To describe the use of gabapentin for treatment of persistent or intractable hiccups in post-stroke patients.
Four cases were identified by clinicians for a retrospective review. A literature review was concurrently conducted.
This case series presents four patients with improvement or resolution of intractable hiccups on gabapentin in a stroke rehabilitation setting. Therapeutic dose ranged from 100 mg TID to 400 mg BID. Treatment duration ranged from 2 days to 5.5 weeks. Adjuncts were used in three of the cases. A potential side effect was worsened confusion in one case.
Evidence on the use of gabapentin for persistent or intractable hiccups is limited. This case series expands on the current literature by examining and comparing the current literature to our cases and exploring issues related to dosing, titration, side effects, and adjuncts to gabapentin.
持续性和顽固性呃逆会极大地影响生活质量，并可能成为中风康复的障碍。氯丙嗪是治疗顽固性呃逆的一线药物，但它可能具有镇静作用，从而对康复参与产生负面影响。加巴喷丁在一些病例报告中已被证明对普通人群和中风后人群的呃逆治疗有效。
描述加巴喷丁在中风后患者中治疗持续性或顽固性呃逆的应用。
通过临床医生确定了四个病例进行回顾性审查。同时进行了文献复习。
本病例系列报告了四名患者在中风康复环境中使用加巴喷丁后呃逆得到改善或缓解。治疗剂量范围为 100 mg TID 至 400 mg BID。治疗持续时间从 2 天到 5.5 周不等。在三个病例中使用了辅助药物。一个潜在的副作用是一例患者的意识混乱加重。
关于加巴喷丁用于持续性或顽固性呃逆的证据有限。本病例系列通过检查和比较当前文献与我们的病例，并探讨与加巴喷丁的剂量、滴定、副作用和辅助药物相关的问题，扩展了当前文献。
