Department of Chemistry, Indian Institute of Technology Indore, Indore 453552, India.
Soft Matter. 2020 Nov 18;16(44):10065-10095. doi: 10.1039/d0sm01136c.
In this review, we have focused on the design and development of low molecular weight self-assembling peptide-based materials for various applications including cell proliferation, tissue engineering, antibacterial, antifungal, anti-inflammatory, anticancer, wound healing, drug delivery, bioimaging and 3D bioprinting. The first part of the review describes about stimuli and various noncovalent interactions, which are the key components of various self-assembly processes for the construction of organized structures. Subsequently, the chemical functionalization of the peptides has been discussed, which is required for the designing of self-assembling peptide-based soft materials. Various low molecular weight self-assembling peptides have been discussed to explain the important structural features for the construction of defined functional nanostructures. Finally, we have discussed various examples of low molecular weight self-assembling peptide-based materials for cell culture, antimicrobial, anti-inflammatory, anticancer, wound healing, drug delivery, bioimaging and 3D bioprinting applications.
在这篇综述中，我们专注于设计和开发基于低分子量自组装肽的材料，这些材料可用于各种应用，包括细胞增殖、组织工程、抗菌、抗真菌、抗炎、抗癌、伤口愈合、药物输送、生物成像和 3D 生物打印。综述的第一部分介绍了刺激物和各种非共价相互作用，它们是构建有组织结构的各种自组装过程的关键组成部分。随后，讨论了肽的化学功能化，这是设计基于自组装肽的软材料所必需的。讨论了各种低分子量自组装肽，以解释构建定义明确的功能纳米结构的重要结构特征。最后，我们讨论了各种基于低分子量自组装肽的材料的例子，这些材料可用于细胞培养、抗菌、抗炎、抗癌、伤口愈合、药物输送、生物成像和 3D 生物打印应用。
