Dalal Deepika, Dahiya Kiran, Malhotra Vani, Aggarwal Sameer, Malik Ashish K, Ahlawat Raunak, Dahiya Priya
Clin Lab. 2020 Oct 1;66(10). doi: 10.7754/Clin.Lab.2020.200243.
Menopause and hypothyroidism, both individually, affect the reproductive hormone profile as well as body metabolism which is reflected in the form of a deranged biochemical profile. It will be interesting to observe the effects on both these profiles, when menopause is associated with hypothyroidism.
This study was conducted on 30 postmenopausal women with newly diagnosed primary hypothyroidism and 30 euthyroid menopausal females as controls. Serum samples of all the subjects were analyzed for complete thyroid profile including total T3 (TT3), total T4 (TT4), free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH), estradiol, progesterone, fasting glucose, renal function tests, liver function tests, and lipid profile. Data of both the groups was compared using Student's t-test.
There was no statistically significant difference observed between the fasting glucose levels and renal and liver function tests in both the groups (p > 0.05). Serum triglycerides, total cholesterol, low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) were found to be significantly increased (p < 0.05) while high density lipoprotein cholesterol (HDL-C), estradiol, and progesterone were found to be significantly decreased (p < 0.05) in menopausal hypothyroid women as compared to their euthyroid counterparts.
Thus, an association of both menopause and hypothyroidism may lead to accentuation of effect of each on biochemical and reproductive hormone profile.
绝经和甲状腺功能减退各自都会影响生殖激素水平以及身体代谢，这以生化指标紊乱的形式体现出来。观察绝经与甲状腺功能减退并存时对这两种指标的影响将会很有意思。
本研究以30名新诊断为原发性甲状腺功能减退的绝经后女性和30名甲状腺功能正常的绝经女性作为对照。分析了所有受试者的血清样本，检测完整的甲状腺指标，包括总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）、雌二醇、孕酮、空腹血糖、肾功能测试、肝功能测试和血脂谱。两组数据采用学生t检验进行比较。
两组的空腹血糖水平以及肾功能和肝功能测试结果均无统计学显著差异（p>0.05）。与甲状腺功能正常的绝经女性相比，绝经后甲状腺功能减退女性的血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）显著升高（p<0.05），而高密度脂蛋白胆固醇（HDL-C）、雌二醇和孕酮显著降低（p<0.05）。
因此，绝经和甲状腺功能减退并存可能会导致二者对生化和生殖激素指标的影响加剧。
