新冠疫情期间德国献血者中严重急性呼吸综合征冠状病毒2特异性抗体的流行情况。
Prevalence of Severe Acute Respiratory Syndrome Coronavirus-2-specific Antibodies in German Blood Donors during the COVID-19 Pandemic.
作者信息
Runkel Stefan, Kowalzik Frank, Gehring Stephan, Winter Julia, Grandt Caine L, Marron Manuela, Seifert-Hitzler Susanne, Hitzler Walter E
出版信息
Clin Lab. 2020 Oct 1;66(10). doi: 10.7754/Clin.Lab.2020.200915.
BACKGROUND
Coronavirus disease-2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While RT-PCR assays are used routinely to diagnose active COVID-19, serological testing offers a means of identifying individuals who previously experienced asymptomatic infections, as well as those who experienced symptomatic infections but no longer carry the virus.
METHODS
The presence of SARS-CoV-2 IgG-positive antibodies in the sera of 673 blood donors residing in south-western Germany before and 3,880 donors after the advent of the COVID-19 pandemic was determined and confirmed using two highly sensitive serological tests.
RESULTS
Approximately 0.40% of the donors assessed during the COVID-19 pandemic possessed SARS-CoV-2 IgG-positive antibodies, decidedly fewer than the percentage of SARS-CoV-2-infected individuals determined by real-time RT-PCR nationwide.
CONCLUSIONS
These findings confirm the efficacy serological testing in identifying asymptomatic COVID-19 patients.
背景
2019冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的呼吸道感染。虽然逆转录聚合酶链反应（RT-PCR）检测通常用于诊断活动性COVID-19，但血清学检测提供了一种方法，可识别先前经历过无症状感染的个体，以及那些经历过有症状感染但不再携带病毒的个体。
方法
使用两种高度敏感的血清学检测方法，确定并确认了德国西南部673名献血者在COVID-19大流行之前和3880名献血者在大流行出现之后血清中SARS-CoV-2 IgG阳性抗体的存在情况。
结果
在COVID-19大流行期间接受评估的献血者中，约0.40%拥有SARS-CoV-2 IgG阳性抗体，明显少于全国通过实时RT-PCR确定的SARS-CoV-2感染个体的百分比。
结论
这些发现证实了血清学检测在识别无症状COVID-19患者方面的有效性。
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