Department of Psychiatry, University of Montreal, Montréal, Quebec, Canada.
Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.
J Pers Disord. 2020 Oct;34(5):609-627. doi: 10.1521/pedi.2020.34.5.609.
The externalizing psychopathological dimension is associated with alterations in adolescents' functional brain connectivity. The current study aims to identify the functional correlates of the unique variability in conduct problems within the context of the broad externalizing dimension. The broad externalizing dimension and unique variability in conduct problems were estimated using a bifactor model. Resting-state data were available for a sample of 125 adolescents. Based on multiresolution parcellation of functional brain networks atlas, major resting-state functional brain networks and the connectivity correlates of unique conduct problems and the broad externalizing dimension were established. The broad externalizing dimension was related to connectivity alterations in the ventral attention/salience network, while unique variability in conduct problems dimension was related to connectivity alterations in the cerebellum crusi as well as the mesolimbic network. The current study is a first step toward the identification of functional resting-state network correlates of broad and specific variability in the externalizing dimension.
外化型精神病理维度与青少年功能性大脑连接改变有关。本研究旨在确定在广泛的外化维度背景下，行为问题独特可变性的功能相关性。使用双因素模型估计了广泛的外化维度和行为问题的独特可变性。为 125 名青少年的样本提供了静息状态数据。基于功能脑网络图谱的多分辨率分割，建立了主要的静息态功能脑网络以及独特的行为问题和广泛的外化维度的连接相关性。广泛的外化维度与腹侧注意/突显网络的连接改变有关，而行为问题维度的独特可变性与小脑 crusii 以及中脑边缘网络的连接改变有关。本研究是确定外化维度广泛和特定可变性的功能静息状态网络相关性的第一步。
