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铁载体掠夺增强了环境生存能力和致病能力。

Siderophore piracy enhances environmental survival and pathogenesis.

作者信息

Byun Hyuntae, Jung I-Ji, Chen Jiandong, Larios Valencia Jessie, Zhu Jay

机构信息

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Microbiology (Reading). 2020 Nov;166(11):1038-1046. doi: 10.1099/mic.0.000975. Epub 2020 Oct 5.

Abstract

the aetiological agent of cholera, possesses multiple iron acquisition systems, including those for the transport of siderophores. How these systems benefit in low-iron, polymicrobial communities in environmental settings or during infection remains poorly understood. Here, we demonstrate that in iron-limiting conditions, co-culture of with a number of individual siderophore-producing microbes significantly promoted growth . We further show that in the host environment with low iron, colonizes better in adult mice in the presence of the siderophore-producing commensal . Taken together, our results suggest that in aquatic reservoirs or during infection, may overcome environmental and host iron restriction by hijacking siderophores from other microbes.

摘要

霍乱的病原体拥有多种铁获取系统,包括那些用于转运铁载体的系统。这些系统如何在环境中或感染期间的低铁、多微生物群落中发挥作用仍知之甚少。在此,我们证明在铁限制条件下,与多种产生铁载体的单个微生物共同培养可显著促进霍乱弧菌的生长。我们进一步表明,在宿主低铁环境中,霍乱弧菌在存在产生铁载体的共生菌的情况下,在成年小鼠中定殖得更好。综上所述,我们的结果表明,在水体储库或感染期间,霍乱弧菌可能通过从其他微生物中获取铁载体来克服环境和宿主的铁限制。

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