Suppr超能文献

铁载体掠夺增强了环境生存能力和致病能力。

Siderophore piracy enhances environmental survival and pathogenesis.

作者信息

Byun Hyuntae, Jung I-Ji, Chen Jiandong, Larios Valencia Jessie, Zhu Jay

机构信息

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Microbiology (Reading). 2020 Nov;166(11):1038-1046. doi: 10.1099/mic.0.000975. Epub 2020 Oct 5.

Abstract

the aetiological agent of cholera, possesses multiple iron acquisition systems, including those for the transport of siderophores. How these systems benefit in low-iron, polymicrobial communities in environmental settings or during infection remains poorly understood. Here, we demonstrate that in iron-limiting conditions, co-culture of with a number of individual siderophore-producing microbes significantly promoted growth . We further show that in the host environment with low iron, colonizes better in adult mice in the presence of the siderophore-producing commensal . Taken together, our results suggest that in aquatic reservoirs or during infection, may overcome environmental and host iron restriction by hijacking siderophores from other microbes.

摘要

霍乱的病原体拥有多种铁获取系统,包括那些用于转运铁载体的系统。这些系统如何在环境中或感染期间的低铁、多微生物群落中发挥作用仍知之甚少。在此,我们证明在铁限制条件下,与多种产生铁载体的单个微生物共同培养可显著促进霍乱弧菌的生长。我们进一步表明,在宿主低铁环境中,霍乱弧菌在存在产生铁载体的共生菌的情况下,在成年小鼠中定殖得更好。综上所述,我们的结果表明,在水体储库或感染期间,霍乱弧菌可能通过从其他微生物中获取铁载体来克服环境和宿主的铁限制。

相似文献

1
Siderophore piracy enhances environmental survival and pathogenesis.
Microbiology (Reading). 2020 Nov;166(11):1038-1046. doi: 10.1099/mic.0.000975. Epub 2020 Oct 5.
2
Catechol Siderophore Transport by Vibrio cholerae.
J Bacteriol. 2015 Sep;197(17):2840-9. doi: 10.1128/JB.00417-15. Epub 2015 Jun 22.
3
The Vibrio cholerae VctPDGC system transports catechol siderophores and a siderophore-free iron ligand.
Mol Microbiol. 2011 Sep;81(6):1446-58. doi: 10.1111/j.1365-2958.2011.07775.x. Epub 2011 Aug 4.
4
Identification of the Vibrio cholerae enterobactin receptors VctA and IrgA: IrgA is not required for virulence.
Infect Immun. 2002 Jul;70(7):3419-26. doi: 10.1128/IAI.70.7.3419-3426.2002.
6
Siderophore-mediated iron acquisition by .
J Bacteriol. 2024 May 23;206(5):e0002424. doi: 10.1128/jb.00024-24. Epub 2024 Apr 9.
7
Iron-binding compounds and related outer membrane proteins in Vibrio cholerae non-O1 strains from aquatic environments.
Appl Environ Microbiol. 1990 Aug;56(8):2410-6. doi: 10.1128/aem.56.8.2410-2416.1990.
8
An iron-regulated outer-membrane protein specific to Bordetella bronchiseptica and homologous to ferric siderophore receptors.
Microbiology (Reading). 1997 Jan;143 ( Pt 1):135-145. doi: 10.1099/00221287-143-1-135.
9
Crystal structure of periplasmic catecholate-siderophore binding protein VctP from Vibrio cholerae at 1.7 Å resolution.
FEBS Lett. 2012 Apr 24;586(8):1240-4. doi: 10.1016/j.febslet.2012.03.043. Epub 2012 Mar 28.

引用本文的文献

1
Probiotic paradox: bacillibactin from drives pathogenic proliferation through siderophore piracy.
ISME Commun. 2025 Aug 1;5(1):ycaf132. doi: 10.1093/ismeco/ycaf132. eCollection 2025 Jan.
2
Iron at the crossroads of host-microbiome interactions in health and disease.
Nat Microbiol. 2025 May 21. doi: 10.1038/s41564-025-02001-y.
3
Xenosiderophores: bridging the gap in microbial iron acquisition strategies.
World J Microbiol Biotechnol. 2025 Feb 13;41(2):69. doi: 10.1007/s11274-025-04287-w.
4
Proteomic Analysis of the Fish Pathogen Strain Vo-LM-18 and Its Outer Membrane Vesicles.
Animals (Basel). 2024 Dec 13;14(24):3598. doi: 10.3390/ani14243598.
5
A long journey to the colon: The role of the small intestine microbiota in intestinal disease.
Mol Microbiol. 2024 Sep;122(3):304-312. doi: 10.1111/mmi.15270. Epub 2024 May 1.
6
A Metabolite Produced by Gut Microbes Represses Phage Infections in .
ACS Chem Biol. 2022 Sep 16;17(9):2396-2403. doi: 10.1021/acschembio.2c00422. Epub 2022 Aug 12.
7
was found in cultured bullfrog.
Epidemiol Infect. 2022 Feb 8;150:e30. doi: 10.1017/S0950268822000164.
8
A-to-I mRNA Editing in a Ferric Siderophore Receptor Improves Competition for Iron in Xanthomonas oryzae pv. .
Microbiol Spectr. 2021 Oct 31;9(2):e0157121. doi: 10.1128/Spectrum.01571-21. Epub 2021 Oct 27.
9
Microbial Musings - November 2020.
Microbiology (Reading). 2020 Nov;166(11):1004-1006. doi: 10.1099/mic.0.001005.

本文引用的文献

1
Potentially human pathogenic Vibrio spp. in a coastal transect: Occurrence and multiple virulence factors.
Sci Total Environ. 2020 Mar 10;707:136113. doi: 10.1016/j.scitotenv.2019.136113. Epub 2019 Dec 13.
2
Bacterial siderophores in community and host interactions.
Nat Rev Microbiol. 2020 Mar;18(3):152-163. doi: 10.1038/s41579-019-0284-4. Epub 2019 Nov 20.
3
Environmental reservoirs of Vibrio cholerae.
Vaccine. 2020 Feb 29;38 Suppl 1:A52-A62. doi: 10.1016/j.vaccine.2019.06.033. Epub 2019 Jul 5.
4
Inland cholera in freshwater environs of north India.
Vaccine. 2020 Feb 29;38 Suppl 1:A63-A72. doi: 10.1016/j.vaccine.2019.06.038. Epub 2019 Jul 3.
5
Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection.
Microbiol Mol Biol Rev. 2019 Jun 5;83(3). doi: 10.1128/MMBR.00007-19. Print 2019 Aug 21.
6
Antagonism toward the intestinal microbiota and its effect on virulence.
Science. 2018 Jan 12;359(6372):210-213. doi: 10.1126/science.aap8775.
7
Iron and infection.
Int J Hematol. 2018 Jan;107(1):7-15. doi: 10.1007/s12185-017-2366-2. Epub 2017 Nov 16.
9
Thiol-based switch mechanism of virulence regulator AphB modulates oxidative stress response in Vibrio cholerae.
Mol Microbiol. 2016 Dec;102(5):939-949. doi: 10.1111/mmi.13524. Epub 2016 Oct 4.
10
Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy.
PLoS One. 2016 Aug 30;11(8):e0161341. doi: 10.1371/journal.pone.0161341. eCollection 2016.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验