Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
ACS Chem Biol. 2022 Sep 16;17(9):2396-2403. doi: 10.1021/acschembio.2c00422. Epub 2022 Aug 12.
is the causative agent of the severe diarrheal disease cholera. Bacteriophages that prey on may be employed as phage therapy against cholera. However, the influence of the chemical environment on the infectivity of vibriophages has been unexplored. Here, we discovered that a common metabolite produced by gut microbes─linear enterobactin (LinEnt), represses vibriophage proliferation. We found that the antiphage effect by LinEnt is due to iron sequestration and that multiple forms of iron sequestration can protect from phage predation. This discovery emphasizes the significance that the chemical environment can have on natural phage infectivity and phage-based interventions.
是严重腹泻病霍乱的病原体。捕食霍乱弧菌的噬菌体可被用作霍乱噬菌体疗法。然而，化学环境对噬菌体感染力的影响尚未得到探索。在这里，我们发现肠道微生物产生的一种常见代谢物——线性肠杆菌素（LinEnt）抑制噬菌体的增殖。我们发现，LinEnt 的抗噬菌体作用是由于铁螯合，并且多种形式的铁螯合可以保护免受噬菌体捕食。这一发现强调了化学环境对自然噬菌体感染力和基于噬菌体的干预措施的重要性。
