How the cytochrome 7a1 (CYP7A1) and ATP-binding cassette G8 (ABCG8) genetic variants affect atorvastatin response among type 2 diabetic patients attending the University of Jordan Hospital.

OBJECTIVE

There is a high inter-individual variation in atorvastatin response. This study aimed to identify the influences of the , , and genetic variants on the lipid profile and atorvastatin response among Arab Jordanian patients with type 2 II diabetes mellitus (T2DM).

MATERIALS AND METHODS

117 patients with T2DM and on atorvastatin therapy, the most common statin used at the University of Jordan Hospital, were genotyped for the , , and genetic variants using PCR-restriction fragment length polymorphism. The baseline blood lipid and glycemic parameters were analyzed in the University of Jordan Hospital's laboratory before and after 3 months of atorvastatin administration.

RESULTS

Patients carrying the homozygote genotype have less total cholesterol (TC) (157.7 mg/dL) and low-density lipoprotein (LDL) (95.5 mg/dL) than the wild genotype (TC (192.4 mg/dL) and LDL (138.3 mg/dL)). Although these differences did not reach statistical significance (ANOVA, p-value > 0.17). There were no significant associations between the and polymorphisms and baseline lipid and glycemic parameters (p > 0.12). Overall, no significant association was found between these polymorphisms and atorvastatin response (p > 0.13).

CONCLUSION

It seems that the , , and genetic variants do not explain the inter-individual variation in atorvastatin response and lipid baseline profile among Jordanian T2DM patients of Arabic origin.