Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany.
J Alzheimers Dis. 2020;78(3):911-917. doi: 10.3233/JAD-200764.
We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.
我们研究了 5394 名年龄≥50 岁的非痴呆个体（2729 名男性；中位年龄 74.2 岁；4716 名认知正常，678 名轻度认知障碍）基线时神经精神症状（NPS）与功能表现纵向变化之间的关系。在调整年龄、性别、教育程度和合并症后，使用神经精神疾病问卷评估的 NPS、临床抑郁（贝克抑郁量表评分≥13）和焦虑（贝克焦虑量表评分≥10）与功能活动问卷评分的增加显著相关，表明随着时间的推移功能下降。这种关联可能因基线时的认知障碍程度而异。
