State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, China.
Mikrochim Acta. 2020 Oct 19;187(11):617. doi: 10.1007/s00604-020-04533-y.
A novel magnetic hollow bimetallic zinc/cobalt-based zeolitic imidazolate framework (MHB-Zn/Co-ZIF-8) was prepared via a microwave-assisted chemical etching in methanol. The structure, morphology, and specific surface area were characterized by X-ray diffraction and FTIR spectroscopy, scanning and transmission electron microscopy, and N adsorption. The hollow nanostructures with high internal specific surface area, abundant active sites, and reduced aggregation of nanoparticles endow the hollow zeolitic imidazolate framework (ZIF) nanoparticle with high chemical stability, desirable durability, and excellent adsorption abilities. The MHB-Zn/Co-ZIF-8 nanoparticle was used as an effective sorbent for magnetic solid-phase extraction (MSPE) of trace aflatoxins B, B, G, and G from fruit juice and fruit samples. The main parameters affecting the efficiency of MSPE procedures were investigated and optimized. The results show that, under optimized conditions, enrichment factors ranging from 67- to 355-fold are obtained for the target analytes. The method is linear in the range 1.0 to 100.0 ng mL with correlation coefficients (R) from 0.9960 to 0.9992. The limits of detection of four aflatoxins are in the range 0.18 to 1.50 ng mL and the average recoveries range from 75.1 to 102.4%, with relative standard deviations (RSDs) less than 13.6%. This work presents the excellent extraction performance of aflatoxins B, B, G, and G on MHB-Zn/Co-ZIF-8. In addition, the applicability of the MSPE coupling with ultrahigh-performance liquid chromatography-ion trap tandem mass spectrometry (UHPLC-IT-MS) for trace analysis in complex matrices is shown. Graphical abstract Schematic presentation of magnetic hollow bimetallic zinc/cobalt zeolitic imidazolate framework as sorbent for efficiently enriching aflatoxins B, B, G, and G from fruit juice samples prior to ultrahigh-performance liquid chromatography-ion trap tandem mass spectrometry (UHPLC-IT-MS) determination.
一种新型的磁性中空双金属锌/钴沸石咪唑酯骨架（MHB-Zn/Co-ZIF-8）通过微波辅助化学刻蚀甲醇制备。通过 X 射线衍射和傅里叶变换红外光谱、扫描和透射电子显微镜以及 N 吸附对其结构、形态和比表面积进行了表征。具有高内比表面积、丰富的活性位点和减少纳米颗粒聚集的中空纳米结构赋予了中空沸石咪唑酯骨架（ZIF）纳米颗粒具有高化学稳定性、理想的耐久性和优异的吸附能力。MHB-Zn/Co-ZIF-8 纳米颗粒被用作从果汁和水果样品中磁性固相萃取（MSPE）痕量黄曲霉毒素 B、B、G 和 G 的有效吸附剂。研究并优化了影响 MSPE 过程效率的主要参数。结果表明，在优化条件下，目标分析物的富集因子范围为 67-355 倍。该方法在线性范围内为 1.0-100.0ngmL，相关系数（R）为 0.9960-0.9992。四种黄曲霉毒素的检出限范围为 0.18-1.50ngmL，平均回收率范围为 75.1-102.4%，相对标准偏差（RSD）小于 13.6%。这项工作展示了 MHB-Zn/Co-ZIF-8 对黄曲霉毒素 B、B、G 和 G 的出色提取性能。此外，还展示了 MSPE 与超高效液相色谱-离子阱串联质谱（UHPLC-IT-MS）联用用于复杂基质中痕量分析的适用性。
