Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Laboratory of Biochemistry, Rabta Hospital, Tunis, Tunisia.
Cancer Invest. 2021 Mar;39(3):240-250. doi: 10.1080/07357907.2020.1839760. Epub 2021 Feb 15.
This cohort study aimed to investigate prognostic significance of plasma folate and cobalamin in non-muscle-invasive bladder cancer (NMIBC). A total of 177 NMIBC patients were followed over a period extending to 6 years. Cox regression models were applied to estimate risks for recurrence and progression according to plasma vitamins tertiles. Compared to first tertile, third tertile of plasma folate [HR (95% CI), 10.5 (1.32-83.4); = 0.026] was associated, and of plasma cobalamin [2.12 (0.63-7.25); = 0.116] tended to be associated with higher risk for progression. NIMBC patients with high folate/cobalamin statuses should make the physician more alert for a likely poor outcome.
本队列研究旨在探讨非肌肉浸润性膀胱癌（NMIBC）患者血浆叶酸和钴胺素的预后意义。共随访了 177 例 NMIBC 患者，随访时间长达 6 年。根据血浆维生素三分位，应用 Cox 回归模型估计复发和进展的风险。与第一三分位相比，血浆叶酸的第三三分位[风险比（95%置信区间），10.5（1.32-83.4）；=0.026]与进展风险升高相关，而血浆钴胺素[2.12（0.63-7.25）；=0.116]则有升高的趋势。叶酸/钴胺素水平较高的 NMIBC 患者可能预示着预后不良，应引起医生的警惕。
