α-甲基对酪氨酸对UChA和UChB大鼠乙醇、水和固体食物自愿摄入量的影响。

Effects of alpha-methylparatyrosine on voluntary consumption of ethanol, water, and solid food in UChA and UChB rats.

作者信息

Contreras S, Alvarado R

出版信息

Alcohol Clin Exp Res. 1987 Jun;11(3):238-9. doi: 10.1111/j.1530-0277.1987.tb01296.x.

DOI:10.1111/j.1530-0277.1987.tb01296.x

Abstract

The effect of daily doses of 80 mg/kg (intraperitoneal) of alpha-methylparatyrosine, AMPT (inhibitor of tyrosine hydroxylase) on the voluntary consumption of ethanol, water, and solid food was studied in rats of both sexes belonging to the UChA (lower ethanol consumer) and UChB (high ethanol consumer) strains. The consumptions during the treatment period were compared to those of the preceding one (basic). Decrease of ethanol and solid food intake and increase of that of water in UChB rats and only a decrease of solid food intake in UChA rats were observed. These effects cannot be ascribed to blocking of dopaminergic or noradrenergic synapses, since this dose of AMPT inhibits the in vivo synthesis of both catecholamines.

摘要

研究了每日腹腔注射80毫克/千克α-甲基对酪氨酸（AMPT，酪氨酸羟化酶抑制剂）对UChA（低乙醇消耗者）和UChB（高乙醇消耗者）品系雌雄大鼠乙醇、水和固体食物自愿摄入量的影响。将治疗期间的摄入量与前一时期（基础期）的摄入量进行了比较。观察到UChB大鼠的乙醇和固体食物摄入量减少，水摄入量增加，而UChA大鼠仅固体食物摄入量减少。这些影响不能归因于多巴胺能或去甲肾上腺素能突触的阻断，因为该剂量的AMPT会抑制体内两种儿茶酚胺的合成。