吡唑对UChA和UChB大鼠乙醇、水和固体食物自愿摄入量的影响。
Effects of pyrazole on the voluntary consumption of ethanol, water and solid food in UChA and UChB rats.
作者信息
Contreras S, Mardones J
机构信息
Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
出版信息
Alcohol. 1988 Sep-Oct;5(5):367-9. doi: 10.1016/0741-8329(88)90022-5.
The effect of pyrazole (35 or 70 mg/kg IP) on the voluntary consumption of ethanol, water and solid food was studied in UChA (genetically low ethanol consumer) and UChB (genetically high ethanol consumer) rats of both sexes, under a free choice of 10% v/v ethanol solution, distilled water and solid food. the data were analyzed according to the method previously proposed for recognizing the specific effect on appetite-satiety of ethanol. The effect of pyrazole in UChB rats correlated with the pattern of specific effects on appetite-satiety for ethanol. The only effect observed in UChA rats was a decrease in the intake of solid food and total water. No significant sex differences were observed.
研究了吡唑（腹腔注射，35或70毫克/千克）对UChA（遗传性低乙醇消耗者）和UChB（遗传性高乙醇消耗者）雌雄大鼠自愿摄取乙醇、水和固体食物的影响，实验中大鼠可自由选择10%（体积/体积）乙醇溶液、蒸馏水和固体食物。根据先前提出的用于识别对乙醇食欲饱腹感的特定影响的方法对数据进行分析。吡唑对UChB大鼠的影响与对乙醇食欲饱腹感的特定影响模式相关。在UChA大鼠中观察到的唯一影响是固体食物和总水摄入量的减少。未观察到显著的性别差异。
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