Knüttgen D, Hossmann V, Doehn M
Anasth Intensivther Notfallmed. 1987 Jun;22(3):124-7.
40 patients of the ASA groups I and II in whom intra-operatively an isorhythmic AV dissociation occurred under inhalation narcosis with halothane or enflurane, were examined in a randomized study. Within an observation period of 15 minutes the spontaneous rate of return to the sinus rhythm was 20 per cent (group A, n = 20). Intravenous administration of 0.01 mg/kg atropine sulphate produced a significantly higher rate of return of 80% within the same period. On the whole, no influence on arterial blood pressure was noted. Atropine increases the heart rate by 32%, and this is considered to be an important drawback. The possibility of influencing the AV dissociation via atropine points to the pathogenetic importance of the vagus in so far as it acts as a depressant on the sinus node.
在一项随机研究中，对40例ASA I级和II级患者进行了检查，这些患者在使用氟烷或恩氟烷进行吸入麻醉时术中出现了等节律性房室分离。在15分钟的观察期内，窦性心律自发恢复率为20%（A组，n = 20）。静脉注射0.01mg/kg硫酸阿托品在同一时期内产生了显著更高的80%的恢复率。总体而言，未观察到对动脉血压的影响。阿托品使心率增加32%，这被认为是一个重要的缺点。通过阿托品影响房室分离的可能性表明，迷走神经在抑制窦房结方面具有发病机制上的重要性。
