From the Department of Pediatrics, Seoul National University Children's Hospital, Seoul.
Department of Pediatrics, Yonsei University Severance Hospital, Seoul.
Pediatr Infect Dis J. 2020 Nov;39(11):1012-1016. doi: 10.1097/INF.0000000000002793.
This study aimed to investigate recent epidemiologic features of Kawasaki disease (KD) in South Korea.
The ninth triennial nationwide questionnaire survey collected data on the demographic findings, symptoms and signs, treatment patterns and coronary artery complications of acute-phase KD occurred in 2015-2017 from 98 hospitals with pediatric residency programs and 108 community hospitals without residency programs.
We received data from 93 of the 98 hospitals (response rate: 94.9%) with residency programs and 75 of the 108 community-based children's hospitals (response rate: 69.4%) without residency programs. In the 3-year survey period, a total of 15,378 (5449 in 2015, 5171 in 2016 and 4758 in 2017) cases of KD were reported. The mean age at diagnosis was 33.0 ± 24.8 months (range: 0-205 months), and the male-to-female ratio was 1.41:1. The overall KD incidence was 196.9 (202.2 in 2015, 197.1 in 2016 and 191.0 in 2017) per 100,000 younger than 5 years population. Recurrent cases were 4.85%. KD occurred more frequently during winter (December-January) and late spring (May-June). Intravenous immunoglobulin (IVIG) was administered to 95% of the patients; nonresponder rate for the first IVIG was 14.8%. Coronary artery aneurysms and giant coronary artery aneurysms (internal diameter >8 mm) occurred in 1.7% and 19 patients, respectively. Two patients died due to multiorgan failure and hepatic encephalopathy.
Peak incidence of KD in South Korea was 202.2 per 100,000 younger than 5 years population (2015), and the incidence of giant coronary artery aneurysm decreased to 0.09% (2017).
本研究旨在调查韩国川崎病（KD）的最新流行病学特征。
第九次三年一度的全国问卷调查收集了 2015-2017 年期间 98 家有儿科住院医师培训计划的医院和 108 家无住院医师培训计划的社区医院中急性川崎病的人口统计学发现、症状和体征、治疗模式和冠状动脉并发症的数据。
我们收到了 98 家有住院医师培训计划的医院中的 93 家（回应率：94.9%）和 108 家无住院医师培训计划的社区儿童医院中的 75 家（回应率：69.4%）的数据。在 3 年的调查期间，共报告了 15378 例（2015 年 5449 例，2016 年 5171 例，2017 年 4758 例）川崎病病例。诊断时的平均年龄为 33.0±24.8 个月（范围：0-205 个月），男女比例为 1.41:1。总川崎病发病率为 196.9（2015 年 202.2，2016 年 197.1，2017 年 191.0）/100000 以下 5 岁人群。复发病例为 4.85%。川崎病在冬季（12 月-1 月）和晚春（5 月-6 月）更为常见。95%的患者接受了静脉注射免疫球蛋白（IVIG）治疗；首次 IVIG 无反应率为 14.8%。冠状动脉瘤和巨大冠状动脉瘤（内径>8mm）分别发生在 1.7%和 19 例患者中。有 2 例患者因多器官衰竭和肝性脑病死亡。
韩国川崎病的发病高峰为每 100000 名 5 岁以下儿童发病 202.2 例（2015 年），巨大冠状动脉瘤的发病率下降至 0.09%（2017 年）。
