Rudakova A V, Malkov M A
Antibiot Med Biotekhnol. 1987 Jun;32(6):434-7.
Parameters of the oleandomycin-producing organism metabolism were studied at the stage of inoculum when intensity of the antibiotic biosynthesis was increased by treating the spores with a surface active substance (twin-21). It was shown that the inoculum producing later at the stage of fermentation higher quantities of the antibiotic was characterized by certain peculiarities. In particular, there were observed a shorter lag phase, a higher specific growth rate and a higher rate of accumulating the medium components at lower pyruvate levels in the exponential phase, higher activity of succinate dehydrogenase and higher levels of ATP in the mycelium during this period.
