[Effect of oleandomycin on the growth of the producer Streptomyces antibioticus itself and on its antibiotic synthesis].

It was shown that addition of oleandomycin to the fermentation broth during development of Str. antibioticus inhibited the mycelium growth within the first 2 days and lowered the level of its further biosynthesis. The inhibitory effect depended on concentration of the added antibiotic and medium composition. An excess of glucose increased the inhibitory effect of oleandomycin. The antibiotic influenced both synthesis of the oleandomycin macrolide ring and methylation of the molecule.