Inoue K, Ogawa M, Horikoshi N, Mukaiyama T, Itoh Y, Imajoh K, Ozeki H, Nagamine D, Shinagawa K
Gan To Kagaku Ryoho. 1987 Sep;14(9):2672-5.
Eight patients with various hematological malignancies were treated with chlorambucil, an analogue of nitrogen mustard. Five patients with CLL, 2 patients with malignant lymphoma, and one each with pseudolymphoma of the lung and primary macroglobulinemia were given 4-6 mg of chlorambucil per day for 1-2 weeks at 2-4 week intervals or a daily dose of 6 mg continuously. Two cases of CLL and one each of follicular lymphoma and pseudolymphoma achieved partial remission. Side effects included myelosuppression, especially leukopenia. Chlorambucil can be used orally without severe toxicity for longer periods and the major indication for this drug seems to be CLL and favorable type of malignant lymphoma.
8例患有各种血液系统恶性肿瘤的患者接受了苯丁酸氮芥（一种氮芥类似物）治疗。5例慢性淋巴细胞白血病（CLL）患者、2例恶性淋巴瘤患者以及1例肺假性淋巴瘤患者和1例原发性巨球蛋白血症患者，以2 - 4周的间隔，每天给予4 - 6毫克苯丁酸氮芥，持续1 - 2周，或每天持续给予6毫克剂量。2例CLL患者、1例滤泡性淋巴瘤患者和1例假性淋巴瘤患者获得部分缓解。副作用包括骨髓抑制，尤其是白细胞减少。苯丁酸氮芥可口服，长期使用无严重毒性，该药物的主要适应证似乎是CLL和某些类型的恶性淋巴瘤。
