Hirano M, Shirakawa S
Gan No Rinsho. 1986 Sep;32(11):1491-4.
Bestrabucil, a chlorambucil-estradiol conjugate known to accumulate in malignant cells irrespective of the presence or absence of estrogen receptor, was administered to a 41-year-old man with follicular lymphoma, medium-sized cell type (LSG classification) stage IV (leukemic). A daily dose of 100 mg was given for two weeks and then 200 mg for a week. The WBC dropped from 43,100/mm3 with 82% abnormal lymphocytes to 12,800/mm3, and the drug was discontinued. It was resumed two weeks later at a daily dose of 50 mg. Four weeks thereafter, complete remission was obtained with the disappearance of all peripheral adenopathies and abnormal cells from the bone marrow. The patient remains disease-free for more than eight months on a maintenance dose of 50 mg per day. Transient erythema and gynecomastia have been the only side effects so far observed.
苯丁酸氮芥，一种已知无论有无雌激素受体均能在恶性细胞中蓄积的苯丁酸氮芥 - 雌二醇共轭物，被用于一名41岁的滤泡性淋巴瘤（中等大小细胞型，LSG分类，IV期（白血病期））男性患者。每日剂量100毫克给药两周，然后200毫克给药一周。白细胞计数从43,100/mm³（异常淋巴细胞占82%）降至12,800/mm³，药物停用。两周后以每日50毫克的剂量恢复用药。此后四周，所有外周淋巴结肿大消失，骨髓中异常细胞消失，实现完全缓解。患者以每日50毫克的维持剂量保持无病状态超过八个月。到目前为止，仅观察到短暂性红斑和男性乳腺增生这两种副作用。
