Shimoyama Y, Kubota T, Inoue S, Kuzuoka M, Ohishi T, Oka S, Kikuyama S, Ishibiki K, Abe O
Gan To Kagaku Ryoho. 1987 Sep;14(9):2682-7.
Experimental chemotherapy with cisplatin and carboplatin was performed against nine human tumor xenografts serially transplanted into nude mice. Tumors used for the experiment were seven gastric (St-4, St-15, St-40, H-111, SC-2-JCK, SC-6-JCK and Exp-4), one breast (MX-1) and one colon (Co-4) carcinomas. Cisplatin 9 mg/kg and carboplatin 100 mg/kg were administered intraperitoneally (ip). Carboplatin 25 mg/kg was also given ip 4 times every 4 days. The efficacy rates of cisplatin and carboplatin by bolus injection were 77.8% and 66.7% respectively with no statistically significant differences. However, carboplatin was found more effective when given by bolus. The antitumor spectra of both drugs were similar. From these results, these two platinum compounds seemed to be effective against human gastric carcinomas.
用顺铂和卡铂对连续移植到裸鼠体内的九种人肿瘤异种移植模型进行了实验性化疗。用于实验的肿瘤包括七种胃癌（St - 4、St - 15、St - 40、H - 111、SC - 2 - JCK、SC - 6 - JCK和Exp - 4）、一种乳腺癌（MX - 1）和一种结肠癌（Co - 4）。顺铂9mg/kg和卡铂100mg/kg通过腹腔注射给药。卡铂25mg/kg也每4天腹腔注射4次。顺铂和卡铂推注给药的有效率分别为77.8%和66.7%，无统计学显著差异。然而，发现卡铂推注给药时更有效。两种药物的抗肿瘤谱相似。从这些结果来看，这两种铂类化合物似乎对人胃癌有效。
